Single-Nuclear RNA Sequencing of Endomyocardial Biopsies Identifies Persistence of Donor-Recipient Chimerism With Distinct Signatures in Severe Cardiac Allograft Vasculopathy

Circ Heart Fail. 2023 Jan;16(1):e010119. doi: 10.1161/CIRCHEARTFAILURE.122.010119. Epub 2022 Dec 16.

Affiliations

¹ Division of Cardiovascular Medicine (K.A., V.A., K.H.S., J.L., R.V.S., J.E.F.), Vanderbilt University Medical Center, Nashville, TN.
² Section of Cardio-Oncology and Immunology, University of California San Francisco (J.Q., J.M.).
³ Masonic Medical Research Institute, Utica, NY (M.L.H., R.D.P., N.R.T.).
⁴ Department of Biostatistics (Q.S., Y.X), Vanderbilt University Medical Center, Nashville, TN.

PMID: 36524467
PMCID: PMC9852032
DOI: 10.1161/CIRCHEARTFAILURE.122.010119

No abstract available

Keywords: allografts; biopsy; fibroblasts; genomics; myocardium.

Publication types

Letter
Research Support, Non-U.S. Gov't
Research Support, N.I.H., Extramural

MeSH terms

Allografts
Biopsy
Chimerism
Graft Rejection / genetics
Heart Failure*
Heart Transplantation* / adverse effects
Humans
Sequence Analysis, RNA

Grants and funding