Emerging roles of intratumor microbiota in cancer metastasis

Aikun Fu; Bingqing Yao; Tingting Dong; Shang Cai

doi:10.1016/j.tcb.2022.11.007

Emerging roles of intratumor microbiota in cancer metastasis

Trends Cell Biol. 2023 Jul;33(7):583-593. doi: 10.1016/j.tcb.2022.11.007. Epub 2022 Dec 14.

Authors

Aikun Fu¹, Bingqing Yao², Tingting Dong², Shang Cai³

Affiliations

¹ Westlake Laboratory of Life Sciences and Biomedicine, Hangzhou, Zhejiang, China; School of Life Sciences, Westlake University, Hangzhou, Zhejiang, China; Key Laboratory of Growth Regulation and Translational Research of Zhejiang Province, School of Life Sciences, Westlake University, Hangzhou, Zhejiang, China; Institute of Biology, Westlake Institute for Advanced Study, Hangzhou, Zhejiang Province, China; Key Laboratory of Animal Nutrition and Feed Science in East China, Ministry of Agriculture, College of Animal Sciences, Zhejiang University, Hangzhou, Zhejiang, China.
² Westlake Laboratory of Life Sciences and Biomedicine, Hangzhou, Zhejiang, China; School of Life Sciences, Westlake University, Hangzhou, Zhejiang, China; Key Laboratory of Growth Regulation and Translational Research of Zhejiang Province, School of Life Sciences, Westlake University, Hangzhou, Zhejiang, China; Institute of Biology, Westlake Institute for Advanced Study, Hangzhou, Zhejiang Province, China.
³ Westlake Laboratory of Life Sciences and Biomedicine, Hangzhou, Zhejiang, China; School of Life Sciences, Westlake University, Hangzhou, Zhejiang, China; Key Laboratory of Growth Regulation and Translational Research of Zhejiang Province, School of Life Sciences, Westlake University, Hangzhou, Zhejiang, China; Institute of Biology, Westlake Institute for Advanced Study, Hangzhou, Zhejiang Province, China; Westlake Disease Modeling lab, Westlake Laboratory of Life Sciences and Biomedicine, Hangzhou, Zhejiang, China. Electronic address: caishang@westlake.edu.cn.

PMID: 36522234
DOI: 10.1016/j.tcb.2022.11.007

Abstract

Cancer metastasis is the leading cause of mortality in patients with cancer. Theories have been developed to explain the causes and principles of metastasis. Metastasis is attributed to cancer cell-intrinsic properties and the extrinsic cellular environment. In recent years, the intratumor microbiota has been identified as an integral tumor component and may functionally regulate various aspects of metastasis. These novel discoveries in intratumor microbiota reshape the framework of our understanding of metastasis and reveal a new path for studies on cancer progression and clinical cancer management. Here, we summarize recent advances in the emerging roles of intratumor microbiota in cancer metastasis and discuss the challenges and implications for cancer treatment.

Keywords: bacteria invasion; cancer ecosystem; cancer metastasis; intracellular bacteria; intratumor microbiota.

Publication types

Review

MeSH terms

Humans
Microbiota*
Neoplasm Metastasis
Neoplasms* / microbiology
Neoplasms* / pathology