Although vertical guided bone regeneration (v-GBR) is a popular technique for treating alveolar bone deficiency, there are no long-term studies analyzing the longevity and success of the results. This retrospective study analyzes the clinical and radiographic outcomes of oxidized implants placed after v-GBR, with a follow-up period of 4 to 15 years. The study considers 41 v-GBR patients receiving one or more dental implants between 2001 and 2013 (115 implants total). Clinical and radiographic outcomes were recorded during follow-up visits. A multiple logistic regression model was used to analyze the correlation between peri-implantitis and demographic, surgical, and clinical variables, as well as the length of the follow-up period. The cumulative survival rate of the implants over the mean follow-up period of 9.6 ± 3.4 years was 95.7%, with peri-implantitis observed in 26.1% of the implants. The variables that correlated with the occurrence of peri-implantitis were smoking (OR = 8.5, 95% CI = 1.6 to 44.5, P < .01), posterior mandible implant position (OR = 2.1, 95% CI = 1.2 to 3.9, P < .01), and the length of the follow-up period (OR = 1.5, 95% CI = 1.1 to 2.2, P < .01). In this study, smoking, time since the surgery, and the implant position were associated with peri-implantitis developing on rough surface implants. Along with with previous long-term follow-up studies, this suggests that oxidized surface implants have a higher risk of peri-implantitis than machined ones.