B(C6F5)3-catalyzed metal-free hydrogenation of 2-oxazolones

Guangyu Cui; Xiangqing Feng; Haifeng Du

doi:10.1039/d2ob01950g

B(C₆F₅)₃-catalyzed metal-free hydrogenation of 2-oxazolones

Org Biomol Chem. 2023 Jan 18;21(3):499-502. doi: 10.1039/d2ob01950g.

Authors

Guangyu Cui^{1

2}, Xiangqing Feng^{1

2}, Haifeng Du^{1

2}

Affiliations

¹ Beijing National Laboratory for Molecular Sciences, CAS Key Laboratory of Molecular Recognition and Function, Institute of Chemistry, Chinese Academy of Sciences, Beijing 100190, China. fxq@iccas.ac.cn.
² University of Chinese Academy of Sciences, Beijing 100049, China.

PMID: 36519305
DOI: 10.1039/d2ob01950g

Abstract

A metal-free hydrogenation of 2-oxazolones was successfully realized by using 10 mol% of B(C₆F₅)₃ as the catalyst, giving a variety of 2-oxazolidinones in 70-98% yields. An enamine to imine process was believed to be involved in this reaction.