Histopathological spectrum of duodenal polyps in a retrospective ten-year study

Varnika Rai; Anurag Saha; Ritu Verma; Vipul Jain; Bhanita Baro

doi:10.15190/d.2022.2

Histopathological spectrum of duodenal polyps in a retrospective ten-year study

Discoveries (Craiova). 2022 Mar 21;10(1):e143. doi: 10.15190/d.2022.2. eCollection 2022 Jan-Mar.

Authors

Varnika Rai¹, Anurag Saha², Ritu Verma¹, Vipul Jain², Bhanita Baro²

Affiliations

¹ Department of Pathology, Sanjay Gandhi Postgraduate Institute of Medical Science, Lucknow, Uttar Pradesh, India.
² Department of Pathology, Topiwala National Medical College and Nair Ch. Hospital, Mumbai, Maharashtra, India.

Abstract

Introduction and aims: Duodenal polyps are rare in patients undergoing upper gastrointestinal endoscopy. The present study is an experience of the histopathological spectrum of the duodenal polyps and its correlation with the clinical and endoscopic findings in a tertiary care centre.

Materials and methods: The present study is a 10-year retrospective study from the year 2011 to 2020. All the relevant clinical, endoscopic and radiologic findings were retrieved from the hospital medical records. Old histopathology slides were restained, and wherever required, special stains and immunohistochemistry (IHC) were performed. All the cases were reviewed. The present study mainly included descriptive statistics with categorical and continuous variables.

Results: Total 81 cases of duodenal polyps were studied in the period of 10 years. The median age was 48 years. Male: female ratio was 2.2:1. The most common presenting system was abdominal pain. We experienced both solitary and multiple polyps. The majority of the duodenal polyps were non-neoplastic, with unremarkable mucosa or inflammatory type. Unlike previous studies the most common site for the hyperplastic polyp in the present study was the first part of the duodenum. Among the neoplastic polyps, adenomatous polyp was the most common type. Contrary to the previous studies, our study showed the first part of the duodenum as the most common site for the sporadic nonampullary adenomatous duodenal polyps. Of the rare entities, we encountered a single case each of lipomatous polyp and gangliocytic paraganglioma. Among the syndromes we encountered two cases of Peutz-Jeghers syndrome and one case of familial adenomatous polyp in our study population.CONCLUSION Duodenal polyps are a rare finding on endoscopic examinations, though most of them are non-neoplastic in nature, vigilant examination under the microcope is required to rule out any neoplastic pathology and identify the risk of malignancy.

Keywords: Upper gastrointestinal (UGI); Institution's Hospital Intranet System (HIS); Hematoxylin and eosin (H and E); Immunohistochemistry (IHC); End staged renal disease (ESRD); Peutz-jeghers (P-J); PTEN hamartoma tumour syndrome (PHTS); Familial adenomatous polyposis (FAP); Neuroendocrine tumour cases (NET); Gastrointestinal stromal tumor (GIST); Gangliocytic paragangliomas (GP); Duodenal lipomas (DL)..