An alphavirus replicon particle delivering prefusion-stabilized spike protein provides potent immunoprotection against SARS-CoV-2 Omicron variant

Signal Transduct Target Ther. 2022 Dec 14;7(1):390. doi: 10.1038/s41392-022-01246-x.

Hong-Qing Zhang^#^{1

2}, Ya-Nan Zhang^#¹, Zhe-Rui Zhang^#¹, Xiao-Ling Chen^{1

2}, Yan-Yan Hu^{1

2}, Yu-Jia Shi^{1

3}, Jing Wang^{1

2}, Cheng-Lin Deng¹, Bo Zhang^{4

5}, Xiao-Dan Li^{6

7}, Han-Qing Ye^{8

9}

¹ Key Laboratory of Special Pathogens and Biosafety, Wuhan Institute of Virology, Center for Biosafety Mega-Science, Chinese Academy of Sciences, Wuhan, China.
² University of Chinese Academy of Sciences, Beijing, 100049, China.
³ Hunan Normal University, School of Medicine, Changsha, 410081, China.
⁴ Key Laboratory of Special Pathogens and Biosafety, Wuhan Institute of Virology, Center for Biosafety Mega-Science, Chinese Academy of Sciences, Wuhan, China. zhangbo@wh.iov.cn.
⁵ University of Chinese Academy of Sciences, Beijing, 100049, China. zhangbo@wh.iov.cn.
⁶ Key Laboratory of Special Pathogens and Biosafety, Wuhan Institute of Virology, Center for Biosafety Mega-Science, Chinese Academy of Sciences, Wuhan, China. lxd@live.cn.
⁷ Hunan Normal University, School of Medicine, Changsha, 410081, China. lxd@live.cn.
⁸ Key Laboratory of Special Pathogens and Biosafety, Wuhan Institute of Virology, Center for Biosafety Mega-Science, Chinese Academy of Sciences, Wuhan, China. yehq@wh.iov.cn.
⁹ University of Chinese Academy of Sciences, Beijing, 100049, China. yehq@wh.iov.cn.

^# Contributed equally.

No abstract available

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