Paternal aging impacts mitochondrial DNA content and telomere length in mouse embryos

Jun Ito; Mio Kageyama; Shunsuke Hara; Takuya Sato; Koumei Shirasuna; Hisataka Iwata

doi:10.1016/j.mito.2022.12.002

Paternal aging impacts mitochondrial DNA content and telomere length in mouse embryos

Mitochondrion. 2023 Jan:68:105-113. doi: 10.1016/j.mito.2022.12.002. Epub 2022 Dec 10.

Authors

Jun Ito¹, Mio Kageyama¹, Shunsuke Hara¹, Takuya Sato¹, Koumei Shirasuna¹, Hisataka Iwata²

Affiliations

¹ Tokyo University of Agriculture, Department of Animal Science, Atsugi, Kanagawa 243-0034, Japan.
² Tokyo University of Agriculture, Department of Animal Science, Atsugi, Kanagawa 243-0034, Japan. Electronic address: h1iwata@nodai.ac.jp.

PMID: 36513246
DOI: 10.1016/j.mito.2022.12.002

Abstract

Mitochondrial DNA (mtDNA) copy number and telomere length (TL) in blastocysts derived from the same male mice at young (10-19-week-old) and aged (40-49-week-old) time points and mtDNA and TL in the hearts of offspring derived from young and aged male mice were examined. Paternal aging correlated with reduced mtDNA and TL in blastocysts. mtDNA and TL were significantly correlated, which was also observed in bovine blastocysts. Moreover, mtDNA in the heart of offspring was reduced in male mice with paternal aging. In conclusion, paternal aging affects embryonic mtDNA and TL, potentially impacting their offspring.

Keywords: Mitochondrial DNA; Mouse embryos; Paternal aging; Telomere length.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Aging / genetics
Animals
Blastocyst
Cattle
DNA, Mitochondrial* / genetics
Male
Mice
Mitochondria / genetics
Telomere* / genetics

Substances

DNA, Mitochondrial