Scientific progress is built on "what went before". As research in a field or discipline progresses, laying strong and scientifically correct foundations for each incremental discovery ultimately accelerates progress. The importance of "research tools" (e.g., chemical probes, antibodies, assays) that underpin researchers' efforts to probe and understand biological systems and pathways should therefore not be underestimated. Appropriate validation, protocol development, and ultimately availability of research tools are critical, in parallel with education on the appropriate selection and use of these tools.