Intermittent fasting increases growth differentiation factor 15 in females with overweight or obesity but not associated with food intake

Kai Liu; Bo Liu; Gary A Wittert; Campbell H Thompson; Amy T Hutchison; Leonie K Heilbronn

doi:10.1016/j.orcp.2022.12.001

Intermittent fasting increases growth differentiation factor 15 in females with overweight or obesity but not associated with food intake

Obes Res Clin Pract. 2023 Jan-Feb;17(1):91-93. doi: 10.1016/j.orcp.2022.12.001. Epub 2022 Dec 9.

Authors

Kai Liu¹, Bo Liu¹, Gary A Wittert¹, Campbell H Thompson², Amy T Hutchison¹, Leonie K Heilbronn³

Affiliations

¹ Adelaide Medical School, University of Adelaide, Adelaide, South Australia 5000, Australia; Lifelong Health Theme, South Australian Health and Medical Research Institute, Adelaide, South Australia 5000, Australia.
² Adelaide Medical School, University of Adelaide, Adelaide, South Australia 5000, Australia.
³ Adelaide Medical School, University of Adelaide, Adelaide, South Australia 5000, Australia; Lifelong Health Theme, South Australian Health and Medical Research Institute, Adelaide, South Australia 5000, Australia. Electronic address: leonie.heilbronn@adelaide.edu.au.

PMID: 36509678
DOI: 10.1016/j.orcp.2022.12.001

Abstract

Growth differentiation factor 15 (GDF15) increases with acute fast in animals, and high GDF15 reduces food intake in rodents. We explored whether GDF15 was altered following intermittent fasting (IF) versus caloric restriction (CR), and associations with energy intake. Females with obesity received all foods at 70% (IF70 and CR70) or 100% of energy requirements for 8 weeks. IF ate 2-9% less than provided on refeeding days, resulting in greater weight losses. GDF15 was increased 5% more in IF70 versus CR70, but not associated with energy intake. This rise in GDF15 is unlikely to explain restriction of energy intake during IF.

Keywords: Calorie restriction; Female; Growth differentiation factor 15; Humans; Intermittent fasting.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Animals
Caloric Restriction
Eating
Energy Intake
Fasting
Female
Growth Differentiation Factor 15
Intermittent Fasting*
Obesity
Overweight*

Substances

Growth Differentiation Factor 15