Effectiveness of vaccines in preventing hospitalization due to COVID-19: A multicenter hospital-based case-control study, Germany, June 2021 to January 2022

Vaccine. 2023 Jan 9;41(2):290-293. doi: 10.1016/j.vaccine.2022.11.065. Epub 2022 Dec 2.

Abstract

We included 852 patients in a prospectively recruiting multicenter matched case-control study in Germany to assess vaccine effectiveness (VE) in preventing COVID-19-associated hospitalization during the Delta-variant dominance. The two-dose VE was 89 % (95 % CI 84-93 %) overall, 79 % in patients with more than two comorbidities and 77 % in adults aged 60-75 years. A third dose increased the VE to more than 93 % in all patient-subgroups.

Keywords: COVID-19; Case-control study; Delta; Hospitalization; SARS-CoV-2; Vaccine effectiveness.

Publication types

  • Multicenter Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • COVID-19* / prevention & control
  • Case-Control Studies
  • Germany / epidemiology
  • Hospitalization
  • Hospitals
  • Humans
  • Vaccines*

Substances

  • Vaccines