Independent euglycaemic hyperinsulinaemic clamp studies validate clinically applicable formulae to estimate insulin sensitivity in people with type 1 diabetes

Andrzej S Januszewski; Pawel Niedzwiecki; Nirupa Sachithanandan; Glenn M Ward; Connie S Karschimkus; David N O'Neal; Dorota A Zozulinska-Ziolkiewicz; Aleksandra A Uruska; Alicia J Jenkins

doi:10.1016/j.dsx.2022.102691

Independent euglycaemic hyperinsulinaemic clamp studies validate clinically applicable formulae to estimate insulin sensitivity in people with type 1 diabetes

Diabetes Metab Syndr. 2023 Jan;17(1):102691. doi: 10.1016/j.dsx.2022.102691. Epub 2022 Dec 5.

Authors

Andrzej S Januszewski¹, Pawel Niedzwiecki², Nirupa Sachithanandan³, Glenn M Ward³, Connie S Karschimkus³, David N O'Neal³, Dorota A Zozulinska-Ziolkiewicz², Aleksandra A Uruska², Alicia J Jenkins⁴

Affiliations

¹ NHMRC Clinical Trials Centre, University of Sydney, Australia; Department of Medicine, University of Melbourne, Australia. Electronic address: andrzej.januszewski@sydney.edu.au.
² Department of Internal Medicine and Diabetology, Poznan University of Medical Sciences, Poland.
³ Department of Medicine, University of Melbourne, Australia.
⁴ NHMRC Clinical Trials Centre, University of Sydney, Australia; Department of Medicine, University of Melbourne, Australia.

PMID: 36508938
DOI: 10.1016/j.dsx.2022.102691

Abstract

Background and aim: Low insulin sensitivity (IS) increases Type 1 diabetes (T1D) complication risk and can be estimated by simple formulae developed from complex euglycemic hyperinsulinaemic clamp studies. We aimed to validate these formulae using independent clamp data.

Methods: Clamps were performed in 104 T1D adults. Measured glucose disposal rate (GDR) was correlated with eGDR and eLog10 M/I calculated by five IS formulae.

Results: Correlations ranged between 0.23-0.40. Two IS formulae (by the authors), using age, sex, HDL-C, HbA1c, pulse pressure, BMI, and waist-hip-ratio had the highest correlation with measured GDR and the best performance in detecting low IS.

MeSH terms

Adult
Blood Glucose
Diabetes Mellitus, Type 1*
Glucose
Glucose Clamp Technique
Humans
Insulin
Insulin Resistance*

Substances

Insulin
Glucose
Blood Glucose