Progress of EGFL6 in angiogenesis and tumor development

Guanyu Su; Wei Wang; Lingjuan Xu; Guigang Li

Progress of EGFL6 in angiogenesis and tumor development

Int J Clin Exp Pathol. 2022 Nov 15;15(11):436-443. eCollection 2022.

Authors

Guanyu Su¹, Wei Wang¹, Lingjuan Xu¹, Guigang Li¹

Affiliation

¹ Department of Ophthalmology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology Wuhan 430030, Hubei, China.

PMID: 36507067
PMCID: PMC9729941

Abstract

The epidermal growth factor (EGF) superfamily includes the protein 6 with an epidermal growth factor-like protein (EGFL6). EGFL6 has a signal peptide domain with an amino terminus and a MAM domain with a carboxy terminus. There are four whole EGF-like repeat regions and one partial EGF-like repeat region. Three of these regions include calcium-binding structures and an arg-gly-asp (RGD) integrin interaction motif. The epidermal growth factor-like (EGFL) and EGF domains have identical amino acid residues. Cell division, differentiation, mortality, cell adhesion, and migration are all affected by EGFL6. EGFL proteins are involved in a broad range of biological activities, making it important in tumor development and angiogenesis. We highlighted the latest development of EGFL6 research on tumor proliferation, invasion, and migration in this review.

Keywords: EGFL6; angiogenesis; tumor.

Publication types

Review