Enigma of otologic immunoglobulin G4-related disease, COVID-19, and uncontrolled diabetes: The unholy trinity

Ashish Jain; Uma Patnaik; Kamalpreet Singh; Jijesh Jayadevan

doi:10.1016/j.mjafi.2022.10.009

Enigma of otologic immunoglobulin G4-related disease, COVID-19, and uncontrolled diabetes: The unholy trinity

Med J Armed Forces India. 2022 Dec 5;80(2):238-241. doi: 10.1016/j.mjafi.2022.10.009. Online ahead of print.

Authors

Ashish Jain¹, Uma Patnaik², Kamalpreet Singh³, Jijesh Jayadevan¹

Affiliations

¹ Resident, Department of ENT, Armed Forces Medical College, Pune, India.
² Professor & Head, Department of ENT, Armed Forces Medical College, Pune, India.
³ Associate Professor, Department of ENT, Armed Forces Medical College, Pune, India.

PMID: 36504510
PMCID: PMC9721396 (available on 2025-03-01)
DOI: 10.1016/j.mjafi.2022.10.009

Abstract

Otologic immunoglobulin G4-related disease (IgG4-RD) is a rare and a relatively newer pathology. COVID-19, IgG4-RD, and type 2 diabetes, all have independent capabilities to considerably affect the immune system. The immunological effects of COVID are a global conundrum; consequently, the association of this trio (otologic IgG4-RD, COVID-19, and type 2 diabetes), the only reported case in literature, paves the way for a fascinating interplay to explore the knowledge of which would help optimize treatment and improve disease outcomes.

Keywords: COVID-19; Immunoglobulin G4–related disease; Type 2 diabetes mellitus.

Publication types

Case Reports