Advances in image-guided drug delivery for antibacterial therapy

Haiyan Huang; Arbab Ali; Yi Liu; Hui Xie; Sana Ullah; Shubham Roy; Zhiyong Song; Bing Guo; Jian Xu

doi:10.1016/j.addr.2022.114634

Advances in image-guided drug delivery for antibacterial therapy

Adv Drug Deliv Rev. 2023 Jan:192:114634. doi: 10.1016/j.addr.2022.114634. Epub 2022 Nov 28.

Authors

Haiyan Huang¹, Arbab Ali², Yi Liu³, Hui Xie⁴, Sana Ullah⁵, Shubham Roy⁶, Zhiyong Song⁷, Bing Guo⁸, Jian Xu⁹

Affiliations

¹ Institute of Low-Dimensional Materials Genome Initiative, College of Chemistry and Environmental Engineering, Shenzhen University, Shenzhen 518060, China; School of Science and Shenzhen Key Laboratory of Flexible Printed Electronics Technology, Harbin Institute of Technology, Shenzhen 518055, China.
² Beijing Key Laboratory of Farmland Soil Pollution Prevention and Remediation, College of Resources and Environmental Sciences, China Agricultural University, Beijing 100193, China; CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nano Safety, CAS Center for Excellence in Nanoscience, National Center for Nanoscience and Technology, Beijing 100190, China.
³ State Key Laboratory of Agricultural Microbiology, College of Science, Huazhong Agricultural University, Wuhan 430070, China.
⁴ Institute of Low-Dimensional Materials Genome Initiative, College of Chemistry and Environmental Engineering, Shenzhen University, Shenzhen 518060, China; Chengdu Institute of Organic Chemistry, Chinese Academy of Sciences, Chengdu 610041, China.
⁵ Department of Biotechnology, Quaid-i-Azam University, Islamabad 45320, Pakistan; Natural and Medical Sciences Research Center, University of Nizwa, P.O. Box: 33, PC: 616, Oman.
⁶ School of Science and Shenzhen Key Laboratory of Flexible Printed Electronics Technology, Harbin Institute of Technology, Shenzhen 518055, China.
⁷ State Key Laboratory of Agricultural Microbiology, College of Science, Huazhong Agricultural University, Wuhan 430070, China. Electronic address: songzhiyong@mail.hzau.edu.cn.
⁸ School of Science and Shenzhen Key Laboratory of Flexible Printed Electronics Technology, Harbin Institute of Technology, Shenzhen 518055, China. Electronic address: guobing2020@hit.edu.cn.
⁹ Institute of Low-Dimensional Materials Genome Initiative, College of Chemistry and Environmental Engineering, Shenzhen University, Shenzhen 518060, China. Electronic address: jxu@iccas.ac.cn.

PMID: 36503884
DOI: 10.1016/j.addr.2022.114634

Abstract

The emergence of antibiotic-resistant bacterial strains is seriously endangering the global healthcare system. There is an urgent need for combining imaging with therapies to realize the real-time monitoring of pathological condition and treatment progress. It also provides guidance on exploring new medicines and enhance treatment strategies to overcome the antibiotic resistance of existing conventional antibiotics. In this review, we provide a thorough overview of the most advanced image-guided approaches for bacterial diagnosis (e.g., computed tomography imaging, magnetic resonance imaging, photoacoustic imaging, ultrasound imaging, fluorescence imaging, positron emission tomography, single photon emission computed tomography imaging, and multiple imaging), and therapies (e.g., photothermal therapy, photodynamic therapy, chemodynamic therapy, sonodynamic therapy, immunotherapy, and multiple therapies). This review focuses on how to design and fabricate photo-responsive materials for improved image-guided bacterial theranostics applications. We present a potential application of different image-guided modalities for both bacterial diagnosis and therapies with representative examples. Finally, we highlighted the current challenges and future perspectives image-guided approaches for future clinical translation of nano-theranostics in bacterial infections therapies. We envision that this review will provide for future development in image-guided systems for bacterial theranostics applications.

Keywords: Bacteria; Imaging; Nanomedicines; Theranostics; Therapy.

Publication types

Review
Research Support, Non-U.S. Gov't

MeSH terms

Anti-Bacterial Agents / pharmacology
Drug Delivery Systems* / methods
Humans
Neoplasms*
Optical Imaging
Positron-Emission Tomography
Theranostic Nanomedicine / methods
Tomography, Emission-Computed, Single-Photon

Substances

Anti-Bacterial Agents