Gutsy sensations modulate intestinal disease

Wang Cao; Gabrielle Belz

doi:10.1016/j.it.2022.11.007

Gutsy sensations modulate intestinal disease

Trends Immunol. 2023 Jan;44(1):1-3. doi: 10.1016/j.it.2022.11.007. Epub 2022 Dec 8.

Authors

Wang Cao¹, Gabrielle Belz²

Affiliations

¹ The Walter and Eliza Hall Institute of Medical Research, Parkville, Melbourne, VIC 3052, Australia; Department of Medical Biology, The University of Melbourne, Melbourne, VIC 3010, Australia.
² The Walter and Eliza Hall Institute of Medical Research, Parkville, Melbourne, VIC 3052, Australia; Department of Medical Biology, The University of Melbourne, Melbourne, VIC 3010, Australia; The University of Queensland Frazer Institute, Faculty of Medicine, The University of Queensland, Brisbane, QLD 4102, Australia. Electronic address: g.belz@uq.edu.au.

PMID: 36503685
DOI: 10.1016/j.it.2022.11.007

Abstract

Pain is a hallmark symptom associated with intestinal inflammation. Two related articles published in Cell by Zhang et al. and by Yang et al. now report how sensory neurons in the gut, the most heavily innervated organ in the human body, flag bacterial pathogens to shape the composition of the gut microbiome and to trigger immunoregulatory mechanisms.

Keywords: enteric nervous system; gastrointestinal immune response; gut immunology; mast cells; neuroimmunology.

Publication types

Research Support, Non-U.S. Gov't
Comment

MeSH terms

Gastrointestinal Microbiome*
Humans
Intestinal Diseases*
Sensation