Effects of fine ambient particulate matters on de novo hypertensive disorders of pregnancy and blood pressure before 20 weeks

Zhichao Yuan; Qin Li; Tao Su; Jie Yang; Junjun Chen; Yuanzhou Peng; Shuang Zhou; Heling Bao; Shusheng Luo; Hui Wang; Jue Liu; Na Han; Yuming Guo; Yuelong Ji; Hai-Jun Wang

doi:10.1016/j.envres.2022.115023

Effects of fine ambient particulate matters on de novo hypertensive disorders of pregnancy and blood pressure before 20 weeks

Environ Res. 2023 Feb 1:218:115023. doi: 10.1016/j.envres.2022.115023. Epub 2022 Dec 8.

Authors

Zhichao Yuan¹, Qin Li¹, Tao Su², Jie Yang², Junjun Chen³, Yuanzhou Peng¹, Shuang Zhou¹, Heling Bao¹, Shusheng Luo¹, Hui Wang¹, Jue Liu⁴, Na Han², Yuming Guo⁵, Yuelong Ji⁶, Hai-Jun Wang⁷

Affiliations

¹ Department of Maternal and Child Health, School of Public Health, Peking University, Beijing, 100191, China.
² Tongzhou Maternal and Child Health Care Hospital of Beijing, Beijing, 101101, China.
³ Department of Maternal and Child Health, School of Public Health, Peking University, Beijing, 100191, China; Department of Electrical and Computer Engineering, Whiting School of Engineering, Johns Hopkins University, Baltimore, MD, 21218, United States.
⁴ Department of Epidemiology and Biostatistics, School of Public Health, Peking University, Beijing, 100191, China.
⁵ Department of Epidemiology and Preventive Medicine, School of Public Health and Preventive Medicine, Monash University, Melbourne, Australia.
⁶ Department of Maternal and Child Health, School of Public Health, Peking University, Beijing, 100191, China. Electronic address: yuelong.ji@pku.edu.cn.
⁷ Department of Maternal and Child Health, School of Public Health, Peking University, Beijing, 100191, China; National Health Commission Key Laboratory of Reproductive Health, Beijing, 100191, China. Electronic address: whjun@pku.edu.cn.

PMID: 36502896
DOI: 10.1016/j.envres.2022.115023

Abstract

The effects of fine particulate matter (PM) on de novo hypertensive disorders of pregnancy (HDP) were inconsistent during the first and second trimesters. This study aimed to assess the trimester-specific effects of PM_2.5 and PM₁ prior to diagnosis of de novo HDP. The exposure of fine PM was predicted by satellite remote sensing data according to maternal residential addresses. De novo HDP was defined as gestational hypertension and preeclampsia during the current pregnancy. A logistic regression model was performed to assess the association of PM_2.5 and PM₁ with HDP during the first and early second trimesters (0-13 weeks and 14-20 weeks). The generalized estimating equation model was conducted to assess the effect of PM_2.5 and PM₁ on blood pressure. The present study included 22,821 pregnant women (mean age, 29.1 years) from 2013 to 2017. PM_2.5 and PM₁ were significantly associated with an increased risk of de novo HDP during the first trimester (OR = 1.070, 95% CI: 1.013-1.130; OR = 1.264, 95% CI: 1.058-1.511 for per 10 μg/m³) and early second trimester (OR = 1.045, 95% CI: 1.003-1.088; OR = 1.170, 95% CI: 1.002-1.366 for per 10 μg/m³). Significant trends of increased de novo HDP risk was also observed with the increment of PM (all P for trend <0.05). The stratified analyses demonstrated that the associations between exposure to fine PM and the risk of HDP were more pronounced among the pregnant women with maternal age above 35 and low maternal education level (all OR >1.047). Each 10 μg/m³ increase of PM₁ and PM_2.5 before diagnosis of de novo HDP elevated 0.204 (95% CI: 0.098-0.310) and 0.058 (95%CI: 0.033-0.083) mmHg of systolic blood pressure. Exposure to PM_2.5 and PM₁ during the first and early second trimester were positively associated with the risk of de novo HDP. The fine PM before diagnosis of de novo HDP elevated the systolic blood pressure.

Keywords: Air pollution; Ambient particulate matters; Hypertensive disorders of pregnancy; Specific trimester.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Adult
Air Pollutants* / analysis
Air Pollutants* / toxicity
Air Pollution* / adverse effects
Air Pollution* / analysis
Blood Pressure
China
Environmental Exposure / analysis
Female
Humans
Hypertension, Pregnancy-Induced* / chemically induced
Maternal Exposure
Particulate Matter / analysis
Particulate Matter / toxicity
Pre-Eclampsia* / chemically induced
Pre-Eclampsia* / epidemiology
Pregnancy

Substances

Particulate Matter
Air Pollutants