Synthesis and characterization of a macromolecular magnetic resonance imaging and delivery system with hyaluronic acid as a carrier

Wan-Yun Fang; You-Yang Zhan; Chuan-Ling Wan; Xiao-Jing Li; Rong Xue; Feng-Kui Pei

doi:10.1016/j.bbrc.2022.11.087

Synthesis and characterization of a macromolecular magnetic resonance imaging and delivery system with hyaluronic acid as a carrier

Biochem Biophys Res Commun. 2023 Jan 8:639:183-188. doi: 10.1016/j.bbrc.2022.11.087. Epub 2022 Nov 29.

Authors

Wan-Yun Fang¹, You-Yang Zhan², Chuan-Ling Wan³, Xiao-Jing Li⁴, Rong Xue², Feng-Kui Pei²

Affiliations

¹ Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, 130022, 5625 Renmin Street, Changchun, Jilin Province, China; School of Applied Chemistry and Engineering, University of Science and Technology of China, Hefei, 230026, China.
² Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, 130022, 5625 Renmin Street, Changchun, Jilin Province, China.
³ College of Science &Technology, Hebei Agricultural University, Huanghua, 061100, China; School of Architecture, Changchun Institute of Technology, Changchun, 130021, China.
⁴ Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, 130022, 5625 Renmin Street, Changchun, Jilin Province, China; School of Applied Chemistry and Engineering, University of Science and Technology of China, Hefei, 230026, China. Electronic address: xjli@ciac.ac.cn.

PMID: 36502552
DOI: 10.1016/j.bbrc.2022.11.087

Abstract

Using hyaluronic acid (HA) as macromolecular drug carriers, a glutathione-responsive imaging drug delivery system HA-SS-a-Gd-DOTA was formed by conjugating gadolinium chelates and cytarabine. This system exhibited T₁-reflexivity (21.9 mmol^-1 L s^-1, 0.5 T) that was higher than that of gadoterate meglumine. In an acidic environment, in vitro drug release reached 63.4% in 24 h. Low cytotoxicity indicated that this system has good biocompatibility. In vivo mouse imaging studies showed that tumor signaling was significantly enhanced. About 58% of the signal enhancement was obtained 50 min after injection of the drug. The degradation of the hyaluronic acid macromolecular chains in vivo makes it an ideal tumor imaging diagnostic agent because it did not cause damage to important organs of the mice.

Keywords: Contrast agent; Hyaluronic acid; MRI; Tumor targets.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Animals
Contrast Media
Hyaluronic Acid
Macromolecular Substances
Magnetic Resonance Imaging / methods
Mice
Neoplasms*
Organometallic Compounds*

Substances

Hyaluronic Acid
Contrast Media
Macromolecular Substances
Organometallic Compounds