Polyoxygenated Terpenoids and Polyketides from the Roots of Flueggea virosa and Their Inhibitory Effect against SARS-CoV-2-Induced Inflammation

Ju-Chien Cheng; Yi-Ju Chen; Chi-Wen Chuang; Ya-Hsuan Chao; Hui-Chi Huang; Chia-Chi Lin; Chih-Hua Chao

doi:10.3390/molecules27238548

Polyoxygenated Terpenoids and Polyketides from the Roots of Flueggea virosa and Their Inhibitory Effect against SARS-CoV-2-Induced Inflammation

Molecules. 2022 Dec 5;27(23):8548. doi: 10.3390/molecules27238548.

Authors

Ju-Chien Cheng¹, Yi-Ju Chen², Chi-Wen Chuang³, Ya-Hsuan Chao¹, Hui-Chi Huang⁴, Chia-Chi Lin⁴, Chih-Hua Chao^{3

5}

Affiliations

¹ Department of Medical Laboratory Science and Biotechnology, China Medical University, Taichung 40402, Taiwan.
² Core Facility Center, Office of Research and Development, Taipei Medical University, Taipei 110301, Taiwan.
³ School of Pharmacy, China Medical University, Taichung 406040, Taiwan.
⁴ Department of Chinese Pharmaceutical Sciences and Chinese Medicine Resources, China Medical University, Taichung 40402, Taiwan.
⁵ Chinese Medicine Research and Development Center, China Medical University Hospital, Taichung 404332, Taiwan.

Abstract

Six new polyoxygenated terpenoids, podovirosanes A-F (1-6), and two known polyketides (7 and 8) were isolated from the roots of F. virosa. Their structures, along with absolute configurations, were deduced using spectroscopic analysis as well as computational calculations, including TDDFT calculation of ECD spectra and GIAO NMR calculations combined with DP4+ probability analysis. Compounds 2, 3, 5, and 8 were found to reduce the phosphorylation levels of NF-κB p65 in SARS-CoV-2 pseudovirus-stimulated PMA-differentiated THP-1 cells.

Keywords: DP4+; Flueggea virosa; SARS-CoV-2; anti-inflammatory; podovirosanes A–F.

MeSH terms

COVID-19*
Euphorbiaceae* / chemistry
Molecular Structure
Polyketides* / pharmacology
SARS-CoV-2
Terpenes / chemistry
Terpenes / pharmacology

Substances

Terpenes
Polyketides

Abstract

MeSH terms

Substances

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