Transformation of Amides to Thioamides Using an Efficient and Novel Thiating Reagent

Mohamed S Gomaa; Gaber El Enany; Walid Fathalla; Ibrahim A I Ali; Samir M El Rayes

doi:10.3390/molecules27238275

Transformation of Amides to Thioamides Using an Efficient and Novel Thiating Reagent

Molecules. 2022 Nov 27;27(23):8275. doi: 10.3390/molecules27238275.

Authors

Mohamed S Gomaa¹, Gaber El Enany^{2

3}, Walid Fathalla³, Ibrahim A I Ali⁴, Samir M El Rayes⁴

Affiliations

¹ Department of Pharmaceutical Chemistry, College of Clinical Pharmacy, Imam Abdulrahman Bin Faisal University, P.O. Box 1982, Dammam 31441, Saudi Arabia.
² Department of Physics, College of Science and Arts in Uglat Asugour, Qassim University, Buraidah 52571, Saudi Arabia.
³ Scientific Department, Faculty of Engineering, Port Said University, Port Said 42526, Egypt.
⁴ Department of Chemistry, Faculty of Science, Suez Canal University, Ismailia 41522, Egypt.

Abstract

A convenient protocol was developed for the transformation of N-aryl-substituted benzamides to N-aryl-substituted benzothioamides using N-isopropyldithiocarbamate isopropyl ammonium salt as a novel thiating reagent. The major advantages of this protocol are its one-pot procedure, short reaction times, mild conditions, simple work-up, high yields and pure products.

Keywords: N-aryl-substituted benzamides; N-isopropyldithiocarbamate isopropyl ammonium salt; benzothioamides; thiating reagent.

MeSH terms

Amides*
Indicators and Reagents
Thioamides*

Substances

Thioamides
Amides
Indicators and Reagents

Grants and funding

This research received no external funding.