A Comparative Study of Urinary Tests and Cultures for the Effectiveness of Fosfomycin in Catheter-Related Urinary Tract Infections

Jung Ki Jo; Dong Seob Kim; Younghun Sim; Soorack Ryu; Kyu Shik Kim

doi:10.3390/jcm11237229

A Comparative Study of Urinary Tests and Cultures for the Effectiveness of Fosfomycin in Catheter-Related Urinary Tract Infections

J Clin Med. 2022 Dec 5;11(23):7229. doi: 10.3390/jcm11237229.

Authors

Jung Ki Jo¹, Dong Seob Kim¹, Younghun Sim¹, Soorack Ryu², Kyu Shik Kim³

Affiliations

¹ Department of Urology, College of Medicine, Hanyang University, Seoul 04763, Republic of Korea.
² Biostatistical Consulting and Research Laboratory, Medical Research Collaborating Center, Hanyang University, Seoul 04763, Republic of Korea.
³ Department of Urology, Hanyang University Guri Hospital, Gyeonggi-do 11923, Republic of Korea.

Abstract

As the elderly population increases due to an aging society, the number of patients with catheters is increasing, and treatment for urinary infections is needed. The current study analyzed the effectiveness of fosfomycin, the primary antibiotic used to treat urinary tract infections (UTIs), in these patients. Patients who received fosfomycin as the primary antibiotic for a UTI were selected, and the results of urine tests and cultures before and after fosfomycin administration were compared and analyzed. The degree of UTI in patients with a catheter was found to be more severe (p = 0.020), and the infecting strains were found to be different depending on whether a catheter was present (p = 0.014). There was a difference in the treatment success rate depending on whether or not a catheter was present (53.6% vs. 70.4%), but it was found that the treatment rate was more than 50% regardless of whether a catheter was present. The bacterial type, as well as the treatment rate based on the bacterium, differed depending on the presence of a catheter. Fosfomycin has a success rate of more than 50%, even in patients with catheters; therefore, it can be considered the primary antibiotic for treating UTIs.

Keywords: catheter; fosfomycin; urinary tract infection; urine culture.

Grants and funding

This work was supported by the Technology Innovation Program, also referred to as the Industrial Strategic Technology Development Program (20016364, Bladder insertion urodynamic testing system for diagnosis of voiding dysfunction), funded by the Ministry of Trade, Industry, and Energy (MOTIE, Korea). This article was also funded by Pharmbio Inc.