The Association of Preoperative PET-CT and Survival in Patients with Resectable Cervical Cancer

Chih-Hsiung Su; Wan-Ming Chen; Ming-Chih Chen; Ben-Chang Shia; Szu-Yuan Wu

doi:10.3390/jcm11237143

The Association of Preoperative PET-CT and Survival in Patients with Resectable Cervical Cancer

J Clin Med. 2022 Dec 1;11(23):7143. doi: 10.3390/jcm11237143.

Authors

Chih-Hsiung Su¹, Wan-Ming Chen^{2

3}, Ming-Chih Chen², Ben-Chang Shia^{2

3}, Szu-Yuan Wu^{2

3

4

5

6

7

8

9

10}

Affiliations

¹ Department of Accounting Information, Chihlee University of Technology, Taipei 220305, Taiwan.
² Graduate Institute of Business Administration, College of Management, Fu Jen Catholic University, Taipei 24205, Taiwan.
³ Artificial Intelligence Development Center, Fu Jen Catholic University, Taipei 24205, Taiwan.
⁴ Department of Food Nutrition and Health Biotechnology, College of Medical and Health Science, Asia University, Taichung 41354, Taiwan.
⁵ Division of Radiation Oncology, Lo-Hsu Medical Foundation, Lotung Poh-Ai Hospital, Yilan County 265010, Taiwan.
⁶ Big Data Center, Lo-Hsu Medical Foundation, Lotung Poh-Ai Hospital, Yilan County 265010, Taiwan.
⁷ Department of Healthcare Administration, College of Medical and Health Science, Asia University, Taichung 41354, Taiwan.
⁸ Cancer Center, Lo-Hsu Medical Foundation, Lotung Poh-Ai Hospital, Yilan County 265010, Taiwan.
⁹ Centers for Regional Anesthesia and Pain Medicine, Taipei Municipal Wan Fang Hospital, Taipei Medical University, Taipei 11031, Taiwan.
¹⁰ Department of Management, College of Management, Fo Guang University, Yilan County 262307, Taiwan.

Abstract

Purpose: No randomized study with a long-term follow-up has investigated the effect of pretreatment 18-fluorodeoxyglucose positron emission tomography-computed tomography (¹⁸FDG-PET-CT) on the survival of patients with stage IB-IIA cervical cancer receiving curative surgery. Therefore, in this propensity score-matched, population-based cohort study, we investigated the effect of preoperative ¹⁸FDG-PET-CT on the survival outcomes of patients with potentially resectable cervical cancer.

Patients and methods: We included 2550 patients with stage IB-IIA cervical cancer receiving curative surgery with complete data on clinical stages. The patients were categorized into two 1:4 propensity, score-matched groups depending on whether they underwent pretreatment ¹⁸FDG-PET-CT, and their outcomes were compared.

Results: We included 2030 and 520 patients with cervical cancer in the non-pretreatment and pretreatment PET-CT groups, respectively. Multivariable analyses revealed that the most prominent correlation between preoperative PET-CT and all-cause death was observed in the patients with stage IB-IIA cervical cancer receiving surgery (aHR [95% CI]: 1.16 [0.83-1.63]; p = 0.3752).

Conclusions: Preoperative ¹⁸FDG-PET-CT was not associated with longer survival in the patients with clinical stage IB-IIA cervical cancer receiving curative surgery.

Keywords: cervical cancer; preoperative 18FDG-PET–CT; stages; surgery; survival.

Grants and funding

This research was funded by Lo-Hsu Medical Foundation, LotungPoh-Ai Hospital, which supports Szu-Yuan Wu’s work (Funding Number: 11001, 11010, 11013 and 11103).