Effects of the Interaction between Affective Temperaments and BIS/BAS on Depressive Symptoms in Individuals with Major Depressive Disorder

Kuniyoshi Toyoshima; Jiro Masuya; Miki Ono; Mina Honyashiki; Shogo Hashimoto; Ichiro Kusumi; Takeshi Inoue

doi:10.3390/ijerph192315841

Effects of the Interaction between Affective Temperaments and BIS/BAS on Depressive Symptoms in Individuals with Major Depressive Disorder

Int J Environ Res Public Health. 2022 Nov 28;19(23):15841. doi: 10.3390/ijerph192315841.

Authors

Kuniyoshi Toyoshima¹, Jiro Masuya², Miki Ono², Mina Honyashiki², Shogo Hashimoto¹, Ichiro Kusumi¹, Takeshi Inoue²

Affiliations

¹ Department of Psychiatry, Graduate School of Medicine, Hokkaido University, Sapporo 060-8638, Japan.
² Department of Psychiatry, Tokyo Medical University, Tokyo 160-0023, Japan.

Abstract

Depressive symptoms (DepS) associated with major depressive disorder (MDD) are influenced by affective temperaments (ATs), behavioral inhibition system (BIS), and behavioral activation system (BAS). However, the effect of interactions between ATs and BIS/BAS on DepS in MDD remains poorly understood. Herein, we aimed to investigate the effects of these interactions. The Temperament Evaluation of Memphis, Pisa, Paris, and San Diego Auto-questionnaire (TEMPS-A), BIS/BAS questionnaire, and Patient Health Questionnaire-9 (PHQ-9) were used to evaluate ATs, BIS/BAS, and DepS, respectively, in 90 participants with MDD. Data were analyzed using hierarchical multiple regression analysis to assess the interaction effect. The interaction (β = 0.199, p < 0.05) between depressive temperament (DepT) (β = 0.319, p < 0.01) and BIS scores (β = 0.300, p < 0.01) exhibited a significant positive effect on DepS (ΔR² = 0.038, p < 0.05). However, the interaction between ATs and BAS scores did not exhibit a significant effect on DepS. Our findings suggest that interactions between BIS sensitivity and DepT worsen DepS in individuals with MDD. Hence, to manage DepS associated with BIS sensitivity and DepT, evaluating their interaction may be useful in daily clinical practice. This study presents important insights into MDD psychopathology.

Keywords: affective temperaments; behavioral activation system; behavioral inhibition system; depression; interaction; major depressive disorder.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Depressive Disorder, Major* / diagnosis
Humans
Inhibition, Psychological
Personality Inventory
Regression Analysis
Surveys and Questionnaires
Temperament

Grants and funding

This work was partially supported by a Grant-in-Aid for Scientific Research from the Japanese Ministry of Education, Culture, Sports, Science and Technology (Grant 16K10194) to T.I.; Research and Development Grants for Comprehensive Research for Persons with Disabilities from the Japan Agency for Medical Research and Development (Grant JP18dk0307060) to T.I.; SENSHIN Medical Research Foundation to T.I.; and JSPS KAKENHI (Grant JP20K16662) to K.T.