Molecular Mechanisms to Target Cellular Senescence in Aging and Disease

Serena Marcozzi; Antonio Paolo Beltrami; Marco Malavolta

doi:10.3390/cells11233732

Molecular Mechanisms to Target Cellular Senescence in Aging and Disease

Cells. 2022 Nov 23;11(23):3732. doi: 10.3390/cells11233732.

Authors

Serena Marcozzi^{1

2}, Antonio Paolo Beltrami³, Marco Malavolta¹

Affiliations

¹ Advanced Technology Center for Aging Research, IRCCS INRCA, 60121 Ancona, Italy.
² Scientific Direction, IRCCS INRCA, 60124 Ancona, Italy.
³ Institute of Clinical Pathology, Department of Medicine (DAME), University of Udine and Azienda Sanitaria Friuli Centrale (ASUFC), 33100 Udine, Italy.

Abstract

Cellular senescence is a state of irreversible cell cycle arrest in response to several stressors, including DNA damage, increased cellular oxidative stress, telomere shortening, oncogene activation, and a deep epigenetic remodeling [...].

Publication types

Editorial

MeSH terms

Cellular Senescence* / genetics
DNA Damage
Telomere Shortening
Telomere*

Grants and funding

This work was supported by Ricerca Corrente funding from Italian Ministry of Health to M.M.