When ferroptosis meets pathogenic infections

Jie Gao; Qiaoban Wang; Yan-Dong Tang; Jingbo Zhai; Wei Hu; Chunfu Zheng

doi:10.1016/j.tim.2022.11.006

When ferroptosis meets pathogenic infections

Trends Microbiol. 2023 May;31(5):468-479. doi: 10.1016/j.tim.2022.11.006. Epub 2022 Dec 7.

Authors

Jie Gao¹, Qiaoban Wang¹, Yan-Dong Tang², Jingbo Zhai³, Wei Hu⁴, Chunfu Zheng⁵

Affiliations

¹ The State Key Laboratory of Reproductive Regulation and Breeding of Grassland Livestock, Inner Mongolia Engineering Technology Research Center of Germplasm Resources Conservation and Utilization, School of Life Sciences, Inner Mongolia University, Hohhot, China.
² State Key Laboratory of Veterinary Biotechnology, Harbin Veterinary Research Institute of Chinese Academy of Agricultural Sciences, Harbin, China.
³ Key Laboratory of Zoonose Prevention and Control at Universities of Inner Mongolia Autonomous Region, Medical College, Inner Mongolia Minzu University, Tongliao, 028000, China.
⁴ The State Key Laboratory of Reproductive Regulation and Breeding of Grassland Livestock, Inner Mongolia Engineering Technology Research Center of Germplasm Resources Conservation and Utilization, School of Life Sciences, Inner Mongolia University, Hohhot, China; State Key Laboratory of Genetic Engineering, Ministry of Education Key Laboratory of Contemporary Anthropology, Collaborative Innovation Center for Genetics and Development, School of Life Sciences, Fudan University, Shanghai, China.
⁵ The State Key Laboratory of Reproductive Regulation and Breeding of Grassland Livestock, Inner Mongolia Engineering Technology Research Center of Germplasm Resources Conservation and Utilization, School of Life Sciences, Inner Mongolia University, Hohhot, China; Institute of Animal Health, Guangdong Academy of Agricultural Sciences, Key Laboratory of Livestock Disease Prevention of Guangdong Province, Scientific Observation and Experiment Station of Veterinary Drugs and Diagnostic Techniques of Guangdong Province, Ministry of Agriculture and Rural Affairs, Guangzhou 510640, China; Department of Microbiology, Immunology and Infectious Diseases, University of Calgary, Alberta, Canada. Electronic address: chunfu.zheng2@ucalgary.ca.

PMID: 36496309
DOI: 10.1016/j.tim.2022.11.006

Abstract

Apoptosis, necrosis, or autophagy are diverse types of regulated cell death (RCD), recognized as the strategies that host cells use to defend against pathogens such as viruses, bacteria, or fungi. Pathogens can induce or block different types of host cell RCD, promoting propagation or evading host immune surveillance. Ferroptosis is a newly identified RCD. Evidence has demonstrated how pathogens regulate ferroptosis to promote their replication, dissemination, and pathogenesis. However, the interaction between ferroptosis and pathogenic infections still needs to be completely elucidated. This review summarizes the advances in the interaction between pathogenic infections and host ferroptotic processes, focusing on the underlying mechanisms of how pathogens exploit ferroptosis, and discussing possible therapeutic measures against pathogen-associated diseases in a ferroptosis-dependent manner.

Keywords: bacteria; ferroptosis; fungi; pathogenesis; pathogenic infection; viruses.

Publication types

Review
Research Support, Non-U.S. Gov't

MeSH terms

Apoptosis
Autophagy
Bacteria
Ferroptosis*
Infections*