TRIM proteins in breast cancer: Function and mechanism

Xin Bai; Jianming Tang

doi:10.1016/j.bbrc.2022.11.103

TRIM proteins in breast cancer: Function and mechanism

Biochem Biophys Res Commun. 2023 Jan 15:640:26-31. doi: 10.1016/j.bbrc.2022.11.103. Epub 2022 Dec 5.

Authors

Xin Bai¹, Jianming Tang²

Affiliations

¹ The First School of Clinical Medicine, Lanzhou University, Lanzhou, Gansu, 730000, PR China.
² The First School of Clinical Medicine, Lanzhou University, Lanzhou, Gansu, 730000, PR China. Electronic address: ldyy_tangjm@lzu.edu.cn.

PMID: 36495607
DOI: 10.1016/j.bbrc.2022.11.103

Abstract

Breast cancer is the most prevalent malignancy in the world, and despite tremendous progress in current treatment strategies, recurrence, metastasis and drug resistance of breast cancer remain the major causes of death in patients. Tripartite motif (TRIM) family proteins play a critical role in the tumor progression such as cell proliferation, migration, invasion, and metastasis. Accumulating evidence suggests that the TRIM protein family serve as cancer suppressor proteins or oncoproteins in breast cancer. This review focused on the roles and molecular mechanisms of TRIM protein in breast cancer. Importantly, it provides new insights that TRIM proteins may be ideal targets to treat breast cancer.

Keywords: Breast cancer; E3 ligase; TRIM proteins; Ubiquitin.

Publication types

Review

MeSH terms

Breast Neoplasms*
Female
Humans
Tripartite Motif Proteins / metabolism
Ubiquitin-Protein Ligases / metabolism

Substances

Tripartite Motif Proteins
Ubiquitin-Protein Ligases