Double jeopardy - pituitary apoplexy complicated by ruptured aneurysm of the internal carotid artery within an adenoma: a case report

BMC Neurol. 2022 Dec 9;22(1):463. doi: 10.1186/s12883-022-02999-2.

Abstract

Background: Sudden onset of severe headache is the most common presentation of a ruptured intracranial aneurysm. Similar symptoms can be caused by pituitary apoplexy, and radiological examination is needed to distinguish between the two. Development of infarction and/or haemorrhage of the hypophysis with concomitant unruptured cerebral aneurysm has been described. However, intratumoural aneurysm within a pituitary adenoma presenting with the ictus of both pathologies is extremely rare.

Case presentation: A 64-year-old man presented with classic symptoms of pituitary apoplexy. His symptoms improved after a few days, and he was discharged. However, he subsequently developed further episodes of sudden and severe headache together with visual decline and ophthalmoplegia. Radiographs demonstrated an enlarging sellar mass with suspicion of a ruptured internal carotid artery aneurysm, within the apoplectic pituitary macroadenoma. Although an endovascular procedure was planned, the patient developed massive subarachnoid haemorrhage resulting in brain death.

Conclusion: This case report describes an intratumoural aneurysm of the cavernous internal carotid artery as a potential cause or result of pituitary apoplexy. Despite its rarity, this possible life-threatening complication of pituitary apoplexy should be recognised for prompt diagnosis and early management.

Keywords: Aneurysm; Case report; Computed tomography; Haemorrhage; Headache; Magnetic resonance imaging; Pituitary neoplasms.

Publication types

  • Case Reports

MeSH terms

  • Adenoma* / complications
  • Adenoma* / diagnostic imaging
  • Adenoma* / surgery
  • Aneurysm, Ruptured* / complications
  • Aneurysm, Ruptured* / diagnostic imaging
  • Aneurysm, Ruptured* / pathology
  • Carotid Artery, Internal / diagnostic imaging
  • Carotid Artery, Internal / pathology
  • Headache / etiology
  • Humans
  • Intracranial Aneurysm* / complications
  • Intracranial Aneurysm* / diagnostic imaging
  • Magnetic Resonance Imaging / methods
  • Male
  • Middle Aged
  • Pituitary Apoplexy* / complications
  • Pituitary Apoplexy* / diagnostic imaging
  • Pituitary Neoplasms* / complications
  • Pituitary Neoplasms* / diagnostic imaging