Cognitive decline and dementia in women after menopause: Prevention strategies

Maturitas. 2023 Feb:168:53-61. doi: 10.1016/j.maturitas.2022.10.012. Epub 2022 Nov 4.

Abstract

Worldwide, cognitive decline and dementia are becoming one of the biggest challenges for public health. The decline in cognition and the development of dementia may be caused by predisposing or trigger factors. There is no consensus over whether the drop in estrogen levels after menopause is a risk factor for cognitive decline and dementia. This article discusses the prevention of cognitive decline and dementia in women after menopause, both primary prevention (essentially pharmacological intervention) and secondary prevention (chiefly diet and weight reduction). Further study is required to clarify whether menopausal hormone therapy (MHT) has a role in dementia.

Keywords: Cognitive decline; Hormone replacement therapy; Menopause.

Publication types

  • Review

MeSH terms

  • Cognitive Dysfunction* / complications
  • Cognitive Dysfunction* / prevention & control
  • Dementia* / drug therapy
  • Dementia* / etiology
  • Dementia* / prevention & control
  • Estrogen Replacement Therapy / adverse effects
  • Estrogens / therapeutic use
  • Female
  • Humans
  • Menopause

Substances

  • Estrogens