Optimization of the biochemical genetics laboratory rotation using a multidesign approach to curriculum

Kerri Bosfield; Jessica Albert; Nancy Cheng; Tiffany Swaringer; Kristina Cusmano-Ozog; Debra S Regier

doi:10.1016/j.gim.2022.11.008

Optimization of the biochemical genetics laboratory rotation using a multidesign approach to curriculum

Genet Med. 2023 Feb;25(2):100340. doi: 10.1016/j.gim.2022.11.008. Epub 2022 Dec 9.

Authors

Kerri Bosfield¹, Jessica Albert², Nancy Cheng³, Tiffany Swaringer³, Kristina Cusmano-Ozog⁴, Debra S Regier⁵

Affiliations

¹ Genetics and Metabolism, University of Tennessee Health Science Center, LeBonheur Children's Hospital, Memphis, TN.
² Pathology and Laboratory Medicine, Children's National Hospital, Washington, DC.
³ Genetics and Metabolism, Rare Disease Institute, Children's National Hospital, Washington, DC.
⁴ Department of Pathology, Stanford University School of Medicine, Stanford, CA.
⁵ Genetics and Metabolism, Rare Disease Institute, Children's National Hospital, Washington, DC. Electronic address: DRegier@childrensnational.org.

PMID: 36484781
DOI: 10.1016/j.gim.2022.11.008

Abstract

Purpose: A biochemical genetics laboratory rotation is required for multiple genetics training programs. Traditionally, this rotation has been observational with experience being dependent upon cases released and availability of laboratory director(s), resulting in inconsistent learning opportunities. This curriculum was created to standardize the learning experience.

Methods: The revised rotation provides multiple teaching modalities including small group didactic sessions (flipped classroom model), case-based sessions, and hands-on laboratory experience. Trainees prepare a presentation (learning by teaching) and discuss the differential diagnosis, metabolic pathway, newborn screening, treatment, and molecular characteristics of the gene(s) implicated. Learner assessment is performed using pre- and post-tests, learner evaluations, and instructor feedback.

Results: Pre- and post-test scores were significantly different (P < .001) for learners from all programs. Participants found the course to be effective, increased their learning, and allowed them to interact with metabolic testing results in helpful ways. Faculty appreciated the use of prerecorded lectures and additional time for in-depth teaching on interesting cases.

Conclusion: The revised rotation has been well received by trainees and faculty. Interaction of learners with the laboratory staff was optimized by ensuring all parties were prepared to teach and learn. Future directions include expanding the program to include remote learners from other centers.

Keywords: Clinical biochemical genetics laboratory; Educational outcomes research; Medical genetics education.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Curriculum*
Humans
Infant, Newborn
Learning*
Molecular Biology
Rotation