Assessment of the effectiveness of ultraviolet-C disinfection on transmission of hospital-acquired pathogens from prior room occupants

Jacob C Hodges; Andrew L Bilderback; Christine M Bridge; Suzanne Wagester; Bonnie V Colaianne; Ahmed Babiker; Tami Minnier; Rachel L Zapf; Paula L Kip; Graham M Snyder

doi:10.1017/ash.2022.254

Assessment of the effectiveness of ultraviolet-C disinfection on transmission of hospital-acquired pathogens from prior room occupants

Antimicrob Steward Healthc Epidemiol. 2022 Jul 7;2(1):e110. doi: 10.1017/ash.2022.254. eCollection 2022.

Authors

Affiliations

¹ Wolff Center, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania.
² Division of Infectious Diseases, Department of Medicine, Emory University School of Medicine, Atlanta, Georgia.
³ Department of Infection Prevention and Control, UPMC Presbyterian Hospital, Pittsburgh, Pennsylvania.
⁴ Division of Infectious Diseases, Department of Medicine, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania.

Abstract

Objective: To evaluate the effectiveness of ultraviolet-C (UV-C) disinfection as an adjunct to standard chlorine-based disinfectant terminal room cleaning in reducing transmission of hospital-acquired multidrug-resistant organisms (MDROs) from a prior room occupant.

Design: A retrospective cohort study was conducted to compare rates of MDRO transmission by UV-C status from January 1, 2016, through December 31, 2018.

Setting: Acute-care, single-patient hospital rooms at 6 hospitals within an academic healthcare system in Pennsylvania.

Methods: Transmission of hospital-acquired MDRO infection was assessed in patients subsequently assigned to a single-patient room of a source occupant with carriage of 1 or more MDROs on or during admission. Acquisition of 5 pathogens was compared between exposed patients in rooms with standard-of-care chlorine-based disinfectant terminal cleaning with or without adjunct UV-C disinfection. Logistic regression analysis was used to estimate the adjusted risk of pathogen transfer with adjunctive use of UV-C disinfection.

Results: In total, 33,771 exposed patient admissions were evaluated; the source occupants carried 46,688 unique pathogens. Prior to the 33,771 patient admissions, 5,802 rooms (17.2%) were treated with adjunct UV-C disinfection. After adjustment for covariates, exposed patients in rooms treated with adjunct UV-C were at comparable risk of transfer of any pathogen (odds ratio, 1.06; 95% CI, 0.84-1.32; P = .64).

Conclusion: Our analysis does not support the use of UV-C in addition to post-discharge cleaning with chlorine-based disinfectant to lower the risk of prior room occupant pathogen transfer.