Evans' syndrome following vaccination with ChAdOx1 nCoV-19 in a patient with new-onset localized scleroderma

Thilo Gambichler; Pia Nordmann; Christina Scheel; Laura Susok

doi:10.4081/dr.2022.9470

Evans' syndrome following vaccination with ChAdOx1 nCoV-19 in a patient with new-onset localized scleroderma

Dermatol Reports. 2022 Nov 21;14(4):9470. doi: 10.4081/dr.2022.9470.

Authors

Thilo Gambichler¹, Pia Nordmann¹, Christina Scheel¹, Laura Susok¹

Affiliation

¹ Skin Cancer Center, Department of Dermatology, Ruhr-University Bochum, Germany.

Abstract

Growing evidence suggests that COVID-19 vaccines can induce hematological conditions. Here, we report a case of Evans' syndrome, a combination of immune thrombocytopenic purpura and autoimmune hemolytic anemia following administration of the ChAdOx1 nCoV-19 vaccine. The present case further supports the notion that COVID-19 vaccines can trigger in rare cases severe persistent autoimmune-mediated hematological conditions which may predominantly occur in patients with underlying autoimmune conditions.

Keywords: COVID-19 vaccination; Evans’; SARSCoV- 2 vaccine; autoimmune hemolytic anemia; immune thrombocytopenic purpura; morphea; scleroderma; syndrome.

Grants and funding

Funding: None.