Abnormal regional homogeneity and amplitude of low frequency fluctuation in chronic kidney patients with and without dialysis

Huan Yu; Chaoyang Zhang; Yan Cai; Ning Wu; Kai Duan; Wenwei Bo; Ying Liu; Zitong Xu

doi:10.3389/fnins.2022.1064813

Abnormal regional homogeneity and amplitude of low frequency fluctuation in chronic kidney patients with and without dialysis

Front Neurosci. 2022 Nov 22:16:1064813. doi: 10.3389/fnins.2022.1064813. eCollection 2022.

Authors

Huan Yu¹, Chaoyang Zhang², Yan Cai³, Ning Wu⁴, Kai Duan¹, Wenwei Bo¹, Ying Liu¹, Zitong Xu¹

Affiliations

¹ Department of Radiology, Liangxiang Hospital, Beijing, China.
² Department of Nephrology, General Hospital of the Chinese People's Liberation Army, Beijing, China.
³ Department of Nephrology, The Affiliated Hospital of Yangzhou University, Yangzhou, China.
⁴ Yanjing Medical College, Capital Medical University, Beijing, China.

Abstract

Purpose: The study characterizes regional homogeneity (ReHo) and amplitude of low frequency fluctuations (ALFF) in abnormal regions of brain in patients of chronic kidney disease (CKD).

Materials and methods: A total of 64 patients of CKD were divided into 26 cases of non-dialysis-dependent chronic kidney disease (NDD-CKD), and 38 cases of dialysis-dependent chronic kidney disease (DD-CKD). A total of 43 healthy controls (normal control, NC) were also included. All subjects underwent resting-state functional magnetic resonance imaging (rs-fMRI). ALFF and ReHo data was processed for monitoring the differences in spontaneous brain activity between the three groups. ALFF and ReHo values of extracted differential brain regions were correlated to the clinical data and cognitive scores of CKD patients.

Results: Non-dialysis-dependent group has increased ALFF levels in 13 brain regions while that of DD group in 28 brain regions as compared with NC group. ReHo values are altered in six brain regions of DD group. ALFF is correlated with urea nitrogen and ReHo with urea nitrogen and creatinine. DD group has altered ReHo in two brain regions compared with NDD group. The differences are located in basal ganglia, cerebellar, and hippocampus regions.

Conclusion: Abnormal activity in basal ganglia, cerebellar, and hippocampal regions may be involved in the cognitive decline of CKD patients. This link can provide theoretical basis for understanding the cognitive decline.

Keywords: amplitude of low frequency; chronic kidney disease; dialysis; regional homogeneity; resting-state functional magnetic resonance imaging.