Management of non-alcoholic fatty liver disease patients with sleep apnea syndrome

World J Gastroenterol. 2022 Nov 21;28(43):6099-6108. doi: 10.3748/wjg.v28.i43.6099.

Abstract

Nonalcoholic fatty liver disease (NAFLD) is strongly associated with sleep apnea syndrome (SAS). Many NAFLD patients have SAS, and obstructive sleep apnea hypopnea syndrome is also considered to be an independent risk factor for NAFLD, as it contributes to the progression of NAFLD via oxidative stress, lipid peroxidation, inflammation, and insulin resistance. This review aims to provide some recommendations for the management of NAFLD patients with SAS, including diet, exercise, weight loss, and continuous positive airway pressure. This review also highlights the importance of effective strategies in NAFLD prevention and treatment.

Keywords: Continuous positive airway pressure; Management; Nonalcoholic fatty liver disease; Obesity; Obstructive sleep apnea hypopnea syndrome; Sleep apnea syndrome.

Publication types

  • Review

MeSH terms

  • Humans
  • Non-alcoholic Fatty Liver Disease* / complications
  • Non-alcoholic Fatty Liver Disease* / diagnosis
  • Non-alcoholic Fatty Liver Disease* / therapy
  • Sleep Apnea Syndromes* / complications
  • Sleep Apnea Syndromes* / diagnosis
  • Sleep Apnea Syndromes* / therapy