Electroretinogram (ERG) to Evaluate the Retina in Cases of Retinitis Pigmentosa (RP)

Methods Mol Biol. 2023:2560:111-122. doi: 10.1007/978-1-0716-2651-1_10.

Abstract

Electroretinogram (ERG) captures the electrical responses of photoreceptors, the summation of action potentials from all neurons in the retina elicited by illumination. ERG testing is an incredibly useful tool in obtaining more specific information regarding a retinal dystrophy. Specifically, ERGs are typically used to test photoreceptors and inner retinal function in humans and animals, to diagnose retinal dystrophies, and to monitor disease progression. In this chapter, we will introduce the components of ERGs and the standard ERG protocols for clinical examination. We will also introduce the various specialized ERG tests, which can help to differentiate retinitis pigmentosa (RP) from other retinal disorders. Lastly, we will elaborate on how to use ERGs to predict visual prognosis in RP.

Keywords: Electroretinogram (ERG); Full-field ERG; Retinitis pigmentosa (RP); The International Society for Clinical Electrophysiology of Vision (ISCEV); a-wave; b-wave.

MeSH terms

  • Electroretinography
  • Humans
  • Retinitis Pigmentosa* / diagnosis
  • Transcriptional Regulator ERG

Substances

  • Transcriptional Regulator ERG