Association of outdoor air pollution, lifestyle, genetic factors with the risk of lung cancer: A prospective cohort study

Huaying Liang; Xin Zhou; Yiqun Zhu; Dianwu Li; Danrong Jing; Xiaoli Su; Pinhua Pan; Hong Liu; Yan Zhang

doi:10.1016/j.envres.2022.114996

Association of outdoor air pollution, lifestyle, genetic factors with the risk of lung cancer: A prospective cohort study

Environ Res. 2023 Feb 1:218:114996. doi: 10.1016/j.envres.2022.114996. Epub 2022 Dec 5.

Authors

Huaying Liang¹, Xin Zhou¹, Yiqun Zhu¹, Dianwu Li¹, Danrong Jing², Xiaoli Su¹, Pinhua Pan³, Hong Liu⁴, Yan Zhang⁵

Affiliations

¹ Department of Respiratory Medicine, National Key Clinical Specialty, Branch of National Clinical Research Center for Respiratory Disease, Xiangya Hospital of Central South University, Changsha, 410008, Hunan, China; Center of Respiratory Medicine, Xiangya Hospital of Central South University, Changsha, 410008, Hunan, China; Clinical Research Center for Respiratory Diseases in Hunan Province, Changsha, 410008, Hunan, China; Hunan Engineering Research Center for Intelligent Diagnosis and Treatment of Respiratory Disease, Changsha, 410008, Hunan, China; National Clinical Research Center for Geriatric Disorders, Xiangya Hospital of Central South University, Changsha, 410008, Hunan, China.
² Department of Dermatology, Xiangya Hospital of Central South University, Changsha, 410008, Hunan, China.
³ Department of Respiratory Medicine, National Key Clinical Specialty, Branch of National Clinical Research Center for Respiratory Disease, Xiangya Hospital of Central South University, Changsha, 410008, Hunan, China; Center of Respiratory Medicine, Xiangya Hospital of Central South University, Changsha, 410008, Hunan, China; Clinical Research Center for Respiratory Diseases in Hunan Province, Changsha, 410008, Hunan, China; Hunan Engineering Research Center for Intelligent Diagnosis and Treatment of Respiratory Disease, Changsha, 410008, Hunan, China; National Clinical Research Center for Geriatric Disorders, Xiangya Hospital of Central South University, Changsha, 410008, Hunan, China. Electronic address: pinhuapan668@csu.edu.cn.
⁴ National Clinical Research Center for Geriatric Disorders, Xiangya Hospital of Central South University, Changsha, 410008, Hunan, China; Department of Dermatology, Xiangya Hospital of Central South University, Changsha, 410008, Hunan, China. Electronic address: hongliu1014@csu.edu.cn.
⁵ Department of Respiratory Medicine, National Key Clinical Specialty, Branch of National Clinical Research Center for Respiratory Disease, Xiangya Hospital of Central South University, Changsha, 410008, Hunan, China; Center of Respiratory Medicine, Xiangya Hospital of Central South University, Changsha, 410008, Hunan, China; Clinical Research Center for Respiratory Diseases in Hunan Province, Changsha, 410008, Hunan, China; Hunan Engineering Research Center for Intelligent Diagnosis and Treatment of Respiratory Disease, Changsha, 410008, Hunan, China; National Clinical Research Center for Geriatric Disorders, Xiangya Hospital of Central South University, Changsha, 410008, Hunan, China. Electronic address: zhangy4290@csu.edu.cn.

PMID: 36481370
DOI: 10.1016/j.envres.2022.114996

Abstract

Objectives: The effect of air pollution exposure on incident lung cancer remains uncertain, and the modifying role of lifestyle and genetic susceptibility in association between air pollution and lung cancer is ambiguous.

Methods: A total of 367,623 participants from UK biobank cohort were enrolled in the analysis. The concentrations of particle matter (PM_2.5, PM₁₀), nitrogen dioxide (NO₂), and nitrogen oxides (NO_x), were evaluated by land-use regression model. Cox proportional hazard model was applied to assess the associations between air pollution and incident lung cancer. A lifestyle risk score and a polygenic risk score were established to investigate whether lifestyle and heritable risk could modify the effect of air pollution on lung cancer risk.

Results: Per interquartile range (IQR) increment in annual concentrations of PM_2.5 (HR = 1.22, 95% CI, 1.15∼1.30), NO₂ (HR = 1.19, 95% CI, 1.10∼1.27), and NO_x (HR = 1.14, 95% CI, 1.09∼1.20) were associated with increased risk of lung cancer. We observed an additive interaction between air pollution including PM_2.5 and NO_x and lifestyle or genetic risk. Individuals with high air pollution exposure, poor lifestyle and high genetic risk had the highest risk of incident lung cancer.

Conclusion: Long-term exposures to air pollution is associated with increased risk of lung cancer, and this effect was modified by lifestyle or genetic risk. Integrated interventions for environmental pollution by government and adherence to healthy lifestyle by individuals are advocated for lung cancer prevention.

Keywords: Air pollution; Genetic risk; Lifestyle; Lung cancer.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Air Pollutants* / analysis
Air Pollutants* / toxicity
Air Pollution* / adverse effects
Air Pollution* / analysis
Cohort Studies
Environmental Exposure / analysis
Humans
Life Style
Lung Neoplasms* / chemically induced
Lung Neoplasms* / epidemiology
Nitrogen Dioxide / analysis
Particulate Matter / analysis
Prospective Studies

Substances

Air Pollutants
Nitrogen Dioxide
Particulate Matter

Abstract

Publication types

MeSH terms

Substances

Grants and funding