Protective role of MG53 against ischemia/reperfusion injury on multiple organs: A narrative review

Bowen Xu; Chunxiao Wang; Hongping Chen; Lihui Zhang; Lei Gong; Lin Zhong; Jun Yang

doi:10.3389/fphys.2022.1018971

Protective role of MG53 against ischemia/reperfusion injury on multiple organs: A narrative review

Front Physiol. 2022 Nov 21:13:1018971. doi: 10.3389/fphys.2022.1018971. eCollection 2022.

Authors

Bowen Xu^{1

2}, Chunxiao Wang², Hongping Chen^{2

3}, Lihui Zhang^{2

3}, Lei Gong², Lin Zhong², Jun Yang²

Affiliations

¹ The 2nd Medical College of Binzhou Medical University, Yantai, Shandong, China.
² Department of Cardiology, Yantai Yuhuangding Hospital, Yantai, Shandong, China.
³ Medical Department of Qingdao University, Qingdao, Shandong, China.

Abstract

Ischemia/reperfusion (I/R) injury is a common clinical problem after coronary angioplasty, cardiopulmonary resuscitation, and organ transplantation, which can lead to cell damage and death. Mitsugumin 53 (MG53), also known as Trim72, is a conservative member of the TRIM family and is highly expressed in mouse skeletal and cardiac muscle, with minimal amounts in humans. MG53 has been proven to be involved in repairing cell membrane damage. It has a protective effect on I/R injury in multiple oxygen-dependent organs, such as the heart, brain, lung, kidney, and liver. Recombinant human MG53 also plays a unique role in I/R, sepsis, and other aspects, which is expected to provide new ideas for related treatment. This article briefly reviews the pathophysiology of I/R injury and how MG53 mitigates multi-organ I/R injury.

Keywords: MG53; ischemia/reperfusion injury (I/R injury); multiple organs; protective; review.

Publication types

Review