dNTP concentrations do not increase in mammalian cells in response to DNA damage

Biswajit Das; Pradeep Mishra; Praveen Pandey; Sushma Sharma; Andrei Chabes

doi:10.1016/j.cmet.2022.11.002

dNTP concentrations do not increase in mammalian cells in response to DNA damage

Cell Metab. 2022 Dec 6;34(12):1895-1896. doi: 10.1016/j.cmet.2022.11.002.

Authors

Biswajit Das¹, Pradeep Mishra¹, Praveen Pandey¹, Sushma Sharma¹, Andrei Chabes²

Affiliations

¹ Department of Medical Biochemistry and Biophysics, Umeå University, 901 87 Umeå, Sweden.
² Department of Medical Biochemistry and Biophysics, Umeå University, 901 87 Umeå, Sweden. Electronic address: andrei.chabes@umu.se.

PMID: 36476929
DOI: 10.1016/j.cmet.2022.11.002

Abstract

A recent publication reported a uniform ∼5- to 6-fold increase in dNTP pools 30 min after exposure to ionizing radiation. Das et al. were not able to reproduce these results. Their data instead agree with earlier publications reporting no increase in dNTP pools in mammalian cells in response to DNA damage.

Publication types

Letter
Research Support, Non-U.S. Gov't
Comment

MeSH terms

DNA Damage*