Is Curcumin a Safe and Effective Therapeutic in the Treatment against Oral Lichen Planus?

Motahareh Khosrojerdi; Eric Gumpricht; Tannaz Jamialahmadi; Prashant Kesharwani; Amirhossein Sahebkar

doi:10.2174/0929867330666221202150727

Is Curcumin a Safe and Effective Therapeutic in the Treatment against Oral Lichen Planus?

Curr Med Chem. 2023;30(15):1684-1688. doi: 10.2174/0929867330666221202150727.

Authors

Motahareh Khosrojerdi¹, Eric Gumpricht², Tannaz Jamialahmadi^{3

4}, Prashant Kesharwani⁵, Amirhossein Sahebkar^{3

6

7

8}

Affiliations

¹ Department of Dentistry, Faculty of Dentistry, Mashhad University of Medical Sciences, Mashhad, Iran.
² Department of Pharmacology, Isagenix International, LLC, Gilbert, Arizona, AZ, 85297, USA.
³ Applied Biomedical Research Center, Mashhad University of Medical Sciences, Mashhad, Iran.
⁴ Surgical Oncology Research Center, Mashhad University of Medical Sciences, Mashhad, Iran.
⁵ Department of Pharmaceutics, School of Pharmaceutical Education and Research, Jamia Hamdard, New Delhi 110062, India.
⁶ Biotechnology Research Center, Pharmaceutical Technology Institute, Mashhad University of Medical Sciences, Mashhad, Iran.
⁷ School of Medicine, The University of Western Australia, Perth, Australia.
⁸ Department of Biotechnology, School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran.

PMID: 36476439
DOI: 10.2174/0929867330666221202150727

Abstract

Oral lichen planus (OLP) is a chronic mucocutaneous, immunological disease that occurs more frequently in the buccal mucosa of middle-aged female patients. OLP's standard treatment is topical or systemic corticosteroids. Due to corticosteroids' numerous potential side effects, there is an effort to find an alternative treatment. One alternative treatment is curcumin. Several studies have investigated the effectiveness and safety of curcumin in OLP patients. In this review, we summarized the literature focusing on the effectiveness and safety of curcumin in OLP patients. Our review of clinical trials revealed that either 6000 mg/day curcumin, 80 mg/day nano-curcumin, or 1% curcumin oral gel 6 times/day offered benefits in the treatment of OLP.

Keywords: Oral lichen planus; buccal mucosa; corticosteroids; curcumin; immunological disease; phytomedicine.

Publication types

Review

MeSH terms

Adrenal Cortex Hormones / therapeutic use
Curcumin*
Female
Humans
Lichen Planus, Oral* / drug therapy
Middle Aged
Mouth Mucosa / chemistry

Substances

Curcumin
Adrenal Cortex Hormones