Longitudinal Virological and Immunological Profile in a Case of Human Monkeypox Infection

Maria Antonella Zingaropoli; Alberico Parente; Blerta Kertusha; Roberta Campagna; Tiziana Tieghi; Silvia Garattini; Raffaella Marocco; Anna Carraro; Eeva Tortellini; Mariasilvia Guardiani; Federica Dominelli; Ombretta Turriziani; Maria Rosa Ciardi; Claudio Maria Mastroianni; Cosmo Del Borgo; Miriam Lichtner

doi:10.1093/ofid/ofac569

Longitudinal Virological and Immunological Profile in a Case of Human Monkeypox Infection

Open Forum Infect Dis. 2022 Nov 1;9(12):ofac569. doi: 10.1093/ofid/ofac569. eCollection 2022 Dec.

Authors

Maria Antonella Zingaropoli¹, Alberico Parente¹, Blerta Kertusha², Roberta Campagna³, Tiziana Tieghi², Silvia Garattini¹, Raffaella Marocco², Anna Carraro¹, Eeva Tortellini¹, Mariasilvia Guardiani¹, Federica Dominelli¹, Ombretta Turriziani³, Maria Rosa Ciardi¹, Claudio Maria Mastroianni¹, Cosmo Del Borgo², Miriam Lichtner^{2

4}

Affiliations

¹ Department of Public Health and Infectious Diseases, Sapienza University of Rome, Rome, Italy.
² Infectious Diseases Unit, SM Goretti Hospital, Sapienza University of Rome, Latina, Italy.
³ Department of Molecular Medicine, Sapienza University of Rome, Rome, Italy.
⁴ Department of Neurosciences, Mental Health, and Sense Organs, NESMOS, University of Rome, Rome, Italy.

Abstract

In a male with severe proctitis, monkeypox virus DNA was detected in skin lesions, blood, the nasopharynx, and the rectum, underlying generalized viral spreading. Rectal involvement was still found when skin lesions disappeared. At this early stage, an increase of cytotoxic and activated T cells was observed, while a reduction in CD56dimCD57+ NK cells compared with recovery time point was observed.

Keywords: MPXV; NK cells; flow cytometry; immunophenotyping; proctitis.