Artificial genetic polymers against human pathologies

Gleb S Ivanov; Vyacheslav G Tribulovich; Nikolay B Pestov; Temitope I David; Abdul-Saleem Amoah; Tatyana V Korneenko; Nikolai A Barlev

doi:10.1186/s13062-022-00353-7

Artificial genetic polymers against human pathologies

Biol Direct. 2022 Dec 6;17(1):39. doi: 10.1186/s13062-022-00353-7.

Authors

Gleb S Ivanov^{1

2}, Vyacheslav G Tribulovich², Nikolay B Pestov^{3

4

5

6}, Temitope I David⁴, Abdul-Saleem Amoah⁴, Tatyana V Korneenko⁵, Nikolai A Barlev^{7

8

9}

Affiliations

¹ Institute of Cytology, Tikhoretsky Ave 4, Saint Petersburg, Russia, 194064.
² St. Petersburg State Technological Institute (Technical University), Saint Petersburg, Russia, 190013.
³ Chumakov Federal Scientific Center for Research and Development of Immune-and-Biological Products, Moscow, Russia, 108819.
⁴ Phystech School of Biological and Medical Physics, Moscow Institute of Physics and Technology, Dolgoprudny, Moscow Region, Russia, 141701.
⁵ Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Moscow, Russia, 117997.
⁶ Institute of Biomedical Chemistry, Moscow, Russia, 119121б.
⁷ Institute of Cytology, Tikhoretsky Ave 4, Saint Petersburg, Russia, 194064. nick.a.barlev@gmail.com.
⁸ Institute of Biomedical Chemistry, Moscow, Russia, 119121б. nick.a.barlev@gmail.com.
⁹ School of Medicine, Nazarbayev University, 010000, Astana, Kazakhstan. nick.a.barlev@gmail.com.

Abstract

Originally discovered by Nielsen in 1991, peptide nucleic acids and other artificial genetic polymers have gained a lot of interest from the scientific community. Due to their unique biophysical features these artificial hybrid polymers are now being employed in various areas of theranostics (therapy and diagnostics). The current review provides an overview of their structure, principles of rational design, and biophysical features as well as highlights the areas of their successful implementation in biology and biomedicine. Finally, the review discusses the areas of improvement that would allow their use as a new class of therapeutics in the future.

Keywords: Locked nucleic acids; Peptide nucleic acids; Xenonucleic acids.

Publication types

Review
Research Support, Non-U.S. Gov't

Grants and funding

No 75-15-2020-913/This work was financed by the Ministry of Science and Higher Education of the Russian Federation within the framework of state support for the creation and development of World-Class Research Centers "Digital Biodesign and Personalized Healthcare"