Advances in the chemical constituents, pharmacological properties and clinical applications of TCM formula Yupingfeng San

Yuxin Bai; Wenlong Wei; Changliang Yao; Shifei Wu; Wei Wang; De-An Guo

doi:10.1016/j.fitote.2022.105385

Advances in the chemical constituents, pharmacological properties and clinical applications of TCM formula Yupingfeng San

Fitoterapia. 2023 Jan:164:105385. doi: 10.1016/j.fitote.2022.105385. Epub 2022 Dec 5.

Authors

Yuxin Bai¹, Wenlong Wei², Changliang Yao², Shifei Wu², Wei Wang³, De-An Guo⁴

Affiliations

¹ College of Pharmaceutical Sciences, Changchun University of Chinese Medicine, Changchun 130117, China; Shanghai Research Center for Modernization of Traditional Chinese Medicine, National Engineering Research Center of TCM Standardization Technology, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China.
² Shanghai Research Center for Modernization of Traditional Chinese Medicine, National Engineering Research Center of TCM Standardization Technology, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China.
³ College of Pharmaceutical Sciences, Changchun University of Chinese Medicine, Changchun 130117, China; TCM and Ethnomedicine Innovation & Development International Laboratory, Innovative Materia Medica Research Institute, School of Pharmacy, Hunan University of Chinese Medicine, Changsha 410208, China.
⁴ College of Pharmaceutical Sciences, Changchun University of Chinese Medicine, Changchun 130117, China; Shanghai Research Center for Modernization of Traditional Chinese Medicine, National Engineering Research Center of TCM Standardization Technology, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China. Electronic address: daguo@simm.ac.cn.

PMID: 36473539
DOI: 10.1016/j.fitote.2022.105385

Abstract

Yupingfeng San (YPFS) is a famous and commonly used traditional Chinese medicine (TCM) formula for the treatment of chronic obstructive pulmonary disease, asthma, respiratory tract infections, and pneumonia in China. It is composed of three Chinese herbs, including Astragali Radix, Atractylodis Macrocephalae Rhizoma and Saposhnikoviae Radix. In this review, the relevant references on YPFS were searched in the Web of Science, PubMed, China National Knowledge Infrastructure (CNKI), and other databases. Literatures published from 2000 to 2022 were screened and summarized. The constituents in YPFS could be classified into nine groups according to their structures, including flavonoids, saponins, essential oils, coumarins, lactones, amino acids, organic acids, saccharides, chromones and others. The importance of chemical constituents in YPFS were demonstrated for specific pathological processes including immunoregulatory, anti-inflammatory, anti-tumor and pulmonary diseases. This article systematically reviewed the up-to-date information on its chemical compositions, pharmacology and safety, that could be used as essential data and reference for clinical applications of YPFS.

Keywords: Chemical constituent; Clinical application; Pharmacology; TCM formula; Yupingfeng san.

Publication types

Review

MeSH terms

Antineoplastic Agents*
Drugs, Chinese Herbal* / chemistry
Medicine, Chinese Traditional
Molecular Structure

Substances

yupingfeng
Drugs, Chinese Herbal
Antineoplastic Agents