The role of O-GlcNAcylation in innate immunity and inflammation

Yongqiang Wang; Xiuwu Fang; Shuai Wang; Bin Wang; Feng Chu; Zhixin Tian; Long Zhang; Fangfang Zhou

doi:10.1093/jmcb/mjac065

The role of O-GlcNAcylation in innate immunity and inflammation

J Mol Cell Biol. 2023 Feb 7;14(9):mjac065. doi: 10.1093/jmcb/mjac065.

Authors

Yongqiang Wang¹, Xiuwu Fang¹, Shuai Wang¹, Bin Wang², Feng Chu¹, Zhixin Tian¹, Long Zhang², Fangfang Zhou¹

Affiliations

¹ Institutes of Biology and Medical Science, Soochow University, Suzhou 215123, China.
² MOE Laboratory of Biosystems Homeostasis and Protection and Innovation Center for Cell Signaling Network, Life Sciences Institute, Zhejiang University, Hangzhou 310058, China.

Abstract

O-linked β-N-acetylglucosaminylation (O-GlcNAcylation) is a highly dynamic and widespread post-translational modification (PTM) that regulates the activity, subcellular localization, and stability of target proteins. O-GlcNAcylation is a reversible PTM controlled by two cycling enzymes: O-linked N-acetylglucosamine transferase and O-GlcNAcase. Emerging evidence indicates that O-GlcNAcylation plays critical roles in innate immunity, inflammatory signaling, and cancer development. O-GlcNAcylation usually occurs on serine/threonine residues, where it interacts with other PTMs, such as phosphorylation. Thus, it likely has a broad regulatory scope. This review discusses the recent research advances regarding the regulatory roles of O-GlcNAcylation in innate immunity and inflammation. A more comprehensive understanding of O-GlcNAcylation could help to optimize therapeutic strategies regarding inflammatory diseases and cancer.

Keywords: O-GlcNAcylation; cancer; inflammation; innate immunity.

Publication types

Review
Research Support, Non-U.S. Gov't

MeSH terms

Acetylglucosamine / metabolism
Humans
Immunity, Innate
Inflammation
Neoplasms*
Phosphorylation
Protein Processing, Post-Translational*

Substances

Acetylglucosamine