An ultrasonic method (20 kHz) is introduced to activate pristine ibuprofen organic molecular crystals via complexation with silver in nitrogen-doped oxidized graphene nanoplatforms (∼50 nm). Ultrasonic complexation occurs in a single-step procedure through the binding of the carboxylic groups with Ag and H-bond formation, involving noncovalent πC=C → πC=C* transitions in the altered phenyl ring and πPY → πCO* in ibuprofen occurring between the phenyl ring and C-O bonds as a result of interaction with hydroxyl radicals. The ibuprofen-silver complex in ≪NrGO≫ exhibits a ∼42 times higher acceleration rate than free ibuprofen of the charge transfer between hexacyanoferrate and thiosulfate ions. The increased acceleration rate can be caused by electron injection/ejection at the interface of the ≪Ag-NrGO≫ nanoplatform and formation of intermediate species (Fe(CN)5(CNSO3)x- with x = 4 or 5 and AgHS2O3) at the excess of produced H+ ions. Important for microwave chemotherapy, ibuprofen-silver complexes in the ≪NrGO≫ nanoplatform can produce H+ ions at ∼12.5 times higher rate at the applied voltage range from 0.53 to 0.60 V. ≪Ibu-Ag-NrGO≫ NPs develop ∼105 order higher changes of the electric field strength intensity than free ibuprofen in the microwave absorption range of 100-1000 MHz as revealed from the theoretical modeling of a cervix tumor tissue.
Keywords: NSAID; catalysis; cervix; graphene; microwave chemotherapy.