Spatiotemporal control over 3D protein nanocage superlattices for the hierarchical encapsulation and release of different cargo molecules

Xiaorong Zhang; Ruiqi Zeng; Tuo Zhang; Chenyan Lv; Jiachen Zang; Guanghua Zhao

doi:10.1039/d2tb01961b

Spatiotemporal control over 3D protein nanocage superlattices for the hierarchical encapsulation and release of different cargo molecules

J Mater Chem B. 2022 Dec 14;10(48):9968-9973. doi: 10.1039/d2tb01961b.

Authors

Xiaorong Zhang¹, Ruiqi Zeng¹, Tuo Zhang¹, Chenyan Lv¹, Jiachen Zang¹, Guanghua Zhao¹

Affiliation

¹ College of Food Science & Nutritional Engineering, China Agricultural University, Beijing Key Laboratory of Functional Food from Plant Resources, Beijing 100083, China. zangjiachen@cau.edu.cn.

PMID: 36472186
DOI: 10.1039/d2tb01961b

Abstract

Taking inspiration from Nature, we have constructed a two-compartment system based on 3D ferritin nanocage superlattices, the self-assembly behavior of which can be spatiotemporally controlled using two designed switches. One pH switch regulates the assembly of the ferritin subunit into its shell-like structure, whereas the other metal switch is responsible for assembly of the 3D superlattices from ferritin nanocages as building blocks. Consequently, this system holds great promise for the hierarchical encapsulation and release of two different cargo molecules.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Ferritins* / chemistry

Substances

Ferritins