Therapeutic in vivo synthetic chemistry using an artificial metalloenzyme with glycosylated human serum albumin

Abstract

The concept of "therapeutic in vivo synthetic chemistry" refers to chemical synthesis in living systems using new-to-nature reactions for the treatment or diagnosis of diseases. This review summarizes our development of therapeutic in vivo synthetic chemistry using glycan-modified human serum albumin (glycoHSA) and utilizing the selective glycan-targeting and metal protective effects of metal catalysts. The four artificial metalloenzymes with glycoHSA provided good cancer treatment results based on on-site drug synthesis and selective cell-tagging strategies. Thus, we propose that therapeutic in vivo synthetic chemistry using glycoHSA as a new modality of therapy or diagnosis is applicable to a wide range of diseases.

Keywords: Artificial metalloenzymes; Cancer therapy; Cell targeting; Glycan-modified human serum albumin; Therapeutic in vivo synthetic chemistry.