Two new sesquiterpene glucosides, 1α,6β,9β-trihydroxy-eudesm-4(15)-en-1,6-O-β-diglucopyranoside (1) and 1α,6β,9β-trihydroxy-eudesm-3-en-1,6-O-β-diglucopyranoside (2) were obtained along with the 1α,6β,9β-trihydroxy-5,10-bis-epi-eudesm-3-en-6-O-β-D-glucopyranoside (3), chlorogenic acid (4), luteolin 7-O-rutinoside (5) and luteolin 7-O- glucoside (6) from the whole plant parts of Lecokia cretica. Their structures were determined on the basis of 1 D, 2 D NMR and HRMS analyses. The in vitro cytotoxic activity of compounds 1-3 against human lung cancer cells (A549) and normal human lung cells (BEAS-2B) was determined using the MTT colorimetric assay. All the tested eudesmane derivatives were found to be inactive.
Keywords: Apiaceae; Lecokia cretica; cell viability; cytotoxic activity; eudesmane; sesquiterpene.