Theoretical and molecular mechanistic investigations of novel (3-(furan-2-yl)pyrazol-4-yl) chalcones against lung carcinoma cell line (A549)

Naunyn Schmiedebergs Arch Pharmacol. 2023 Apr;396(4):719-736. doi: 10.1007/s00210-022-02344-x. Epub 2022 Dec 5.

Abstract

A new chalcone series has been developed that may be useful in the treatment of lung cancer. The new series was confirmed by the different spectral tools. MTT assay was used to detect the cytotoxic effect of the novel chalcones against lung cancer cell line (A549). Molecular docking studies were performed on the most two effective chalcones 7b and 7c. Different molecular techniques were utilized to study the activity and the effect of two chalcones 7b and 7c on apoptosis of A549 cell line.

Keywords: (3-(Furan-2-yl)pyrazol-4-yl)chalcone; A549; Docking studies; MTT assay; Two mechanism of apoptosis.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • A549 Cells
  • Antineoplastic Agents* / pharmacology
  • Antineoplastic Agents* / therapeutic use
  • Apoptosis
  • Carcinoma*
  • Cell Line, Tumor
  • Cell Proliferation
  • Chalcones* / pharmacology
  • Chalcones* / therapeutic use
  • Furans / pharmacology
  • Humans
  • Lung / pathology
  • Lung Neoplasms* / drug therapy
  • Lung Neoplasms* / pathology
  • Molecular Docking Simulation
  • Structure-Activity Relationship

Substances

  • Chalcones
  • Furans
  • Antineoplastic Agents