Is thrombocytopenia and postnatal weight gain associated with treatment-requiring retinopathy of prematurity? A matched case-control study

Aikaterini K Seliniotaki; Maria Lithoxopoulou; Stella Moutzouri; Emmanouil Bouras; Elisavet Diamanti; Nikolaos Ziakas; Pia Lundgren; Ann Hellström; Anna-Bettina Haidich; Asimina Mataftsi

doi:10.1111/aos.15302

Is thrombocytopenia and postnatal weight gain associated with treatment-requiring retinopathy of prematurity? A matched case-control study

Acta Ophthalmol. 2023 Jun;101(4):433-442. doi: 10.1111/aos.15302. Epub 2022 Dec 5.

Affiliations

¹ 2nd Department of Ophthalmology, School of Medicine, Faculty of Health Sciences, Aristotle University of Thessaloniki, Thessaloniki, Greece.
² Department of Hygiene, Social-Preventive Medicine & Medical Statistics, School of Medicine, Faculty of Health Sciences, Aristotle University of Thessaloniki, Thessaloniki, Greece.
³ 2nd Department of Neonatology, School of Medicine, Faculty of Health Sciences, Aristotle University of Thessaloniki, Thessaloniki, Greece.
⁴ Department of Clinical Neuroscience, The Sahlgrenska Centre for Pediatric Ophthalmology Research, Institute of Neuroscience and Physiology, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.

PMID: 36468823
DOI: 10.1111/aos.15302

Abstract

Purpose: The purpose of the study was to investigate the association of platelet parameters and postnatal weight gain with treatment-requiring ROP (TR-ROP).

Methods: In this retrospective matched case-control study, infants with TR-ROP were individually matched, according to gestational age and birth weight, with one or two untreated infants who developed no or spontaneously regressed ROP. Longitudinal data on platelet count (PLT), mean platelet volume (MPV), daily weight and platelet transfusions were collected. Platelet mass index (PMI) and weight standard deviation score (WSDS) were also calculated. Conditional logistic regression analysis was performed to adjust for matching.

Results: Fourteen cases, presenting type I ROP, and 25 matched controls were included. The odds of developing TR-ROP decreased as PLT increased during 31^st week of postmenstrual age (PMA) or during 1^st and 2^nd week of postnatal age (PNA). The odds of developing TR-ROP were 16.7 times higher in infants receiving at least one platelet transfusion compared with those who were not transfused. The odds of developing TR-ROP increased by 31.2% as the mean volume of platelet transfusion per infant increased by 1 ml. The odds of developing TR-ROP decreased as PMI increased during 1^st week PNA, and as weight and WSDS increased during 4^th -6^th week PNA. Analysis of MPV, number of thrombopenic episodes per infant, number of platelet transfusions per infant and days with WSDS < -2 showed no association with TR-ROP.

Conclusion: To our knowledge, this is the first study ascertaining an association of platelet transfusions with type I ROP. Prospective cohort studies are required to confirm our findings.

Keywords: ROP; platelets; thrombocytopenia; thrombopenic; transfusion; weight gain.

MeSH terms

Birth Weight
Case-Control Studies
Gestational Age
Humans
Infant
Infant, Newborn
Prospective Studies
Retinopathy of Prematurity* / complications
Retinopathy of Prematurity* / diagnosis
Retinopathy of Prematurity* / therapy
Retrospective Studies
Risk Factors
Thrombocytopenia* / complications
Weight Gain