Antioxidant effects of continuous intake of electrolyzed hydrogen water in healthy adults

Kei Mizuno; Kyosuke Watanabe; Emi Yamano; Kyoko Ebisu; Kanako Tajima; Junzo Nojima; Yusuke Ohsaki; Shigeru Kabayama; Yasuyoshi Watanabe

doi:10.1016/j.heliyon.2022.e11853

Antioxidant effects of continuous intake of electrolyzed hydrogen water in healthy adults

Heliyon. 2022 Nov 25;8(11):e11853. doi: 10.1016/j.heliyon.2022.e11853. eCollection 2022 Nov.

Authors

Kei Mizuno^{1

2

3}, Kyosuke Watanabe^{1

2

3}, Emi Yamano^{1

2

3}, Kyoko Ebisu^{1

2}, Kanako Tajima^{1

2}, Junzo Nojima⁴, Yusuke Ohsaki⁵, Shigeru Kabayama⁶, Yasuyoshi Watanabe^{1

2

3}

Affiliations

¹ Laboratory for Pathophysiological and Health Science, RIKEN Center for Biosystems Dynamics Research, 6-7-3 Minatojima-minamimachi, Chuo-ku, Kobe City, Hyogo 650-0047, Japan.
² RIKEN Compass to Healthy Life Research Complex Program, 6-7-1 Minatojima-minamimachi, Chuo-ku, Kobe City, Hyogo 650-0047, Japan.
³ Osaka City University Center for Health Science Innovation, 3-1 Ofuka-cho, Kita-ku, Osaka City, Osaka 530-0011, Japan.
⁴ Department of Laboratory Science, Faculty of Health Science, Yamaguchi University Graduate School of Medicine, 1-1-1 Minami-kogushi, Ube City, Yamaguchi 755-8505, Japan.
⁵ Laboratory of Nutrition, Graduate School of Agricultural Science, Tohoku University, 468-1 Aramaki Aza Aoba, Aoba-ku, Sendai City, Miyagi 980-8572, Japan.
⁶ Trim Medical Institute Co. Ltd., 22F HERBIS ENT Office Tower 2-2-22 Umeda, Osaka City, Osaka 530-0001, Japan.

Abstract

Chronic oxidative stress induces deterioration of health and a risk for the onset of various diseases. Previous clinical studies revealed that electrolyzed hydrogen water (EHW) is effective to reduce oxidative stress during hemodialysis in patients with chronic dialysis. In the present observational study, we investigated the antioxidant effects of a daily continuous intake of EHW in healthy adults. The concentrations of serum reactive oxygen metabolites-derived compounds (d-ROMs) and blood urea nitrogen in healthy volunteers (n = 64) who had a habit of intake over 500 mL/day of EHW at least 5 days a week for longer than 6 months were lower than those of age- and sex-matched controls (n = 470) without the habit of EHW intake. Oxidation stress index which the ratio between concentrations in d-ROMs and biological antioxidant potential was correlated with the serum concentration of high-sensitivity C-reactive protein or low-density lipoprotein cholesterol in the EHW group. These results suggest that the continuous intake of EHW induces antioxidant effects and may contribute to alleviate the risk of various oxidative stress-related dysfunctions and diseases in healthy adults.

Keywords: Antioxidant oxidative stress; Electrolyzed hydrogen water; Inflammation; LDL cholesterol; Renal function.