The roles of lncRNA functions and regulatory mechanisms in the diagnosis and treatment of hepatocellular carcinoma

Yuling Hong; Yunxing Zhang; Haibo Zhao; Hailing Chen; Qing-Qing Yu; Hongxia Cui

doi:10.3389/fcell.2022.1051306

The roles of lncRNA functions and regulatory mechanisms in the diagnosis and treatment of hepatocellular carcinoma

Front Cell Dev Biol. 2022 Nov 18:10:1051306. doi: 10.3389/fcell.2022.1051306. eCollection 2022.

Authors

Yuling Hong¹, Yunxing Zhang², Haibo Zhao², Hailing Chen¹, Qing-Qing Yu², Hongxia Cui²

Affiliations

¹ School of Clinical Medicine, Jining Medical University, Jining, China.
² Jining First People's Hospital, Jining Medical College, Jining, China.

Abstract

Hepatocellular carcinoma (HCC) is the most frequent and deadly type of liver cancer. While the underlying molecular mechanisms are poorly understood, it is documented that lncRNAs may play key roles. Many HCC-associated lncRNAs have been linked to HBV and HCV infection, mediating gene expression, cell growth, development, and death. Studying the regulatory mechanisms and biological functions of HCC-related lncRNAs will assist our understanding of HCC pathogenesis as well as its diagnosis and management. Here, we address the potential of dysregulated lncRNAs in HCC as diagnostic and therapeutic biomarkers, and we evaluate the oncogenic or tumor-suppressive properties of these lncRNAs.

Keywords: biomarker; diagnosis and therapy; gene expression regulation; hepatocellular carcinoma; long noncoding RNA.

Publication types

Review