Aged garlic extract as a potential prophylactic to reduce the progression of endometriosis and associated pain burden

Emily Redwood; Virginie Lam; Ryusuke Takechi; Deborah Anne Kerr; Connie Jackaman; Arazu Sharif; John Charles Louis Mamo

doi:10.3389/fpain.2022.1057830

Aged garlic extract as a potential prophylactic to reduce the progression of endometriosis and associated pain burden

Front Pain Res (Lausanne). 2022 Nov 17:3:1057830. doi: 10.3389/fpain.2022.1057830. eCollection 2022.

Authors

Emily Redwood^{1

2}, Virginie Lam^{1

2}, Ryusuke Takechi^{1

2}, Deborah Anne Kerr^{1

2}, Connie Jackaman^{2

3}, Arazu Sharif^{2

3}, John Charles Louis Mamo^{1

2}

Affiliations

¹ School of Population Health, Curtin University, Perth, WA, Australia.
² Curtin Health Innovation Research Institute, Curtin University, Perth, WA, Australia.
³ Curtin Medical School, Curtin University, Perth, WA, Australia.

Abstract

Endometriosis is a complex and potentially debilitating condition that has major impact on quality of life. There is emerging evidence that biological compounds found in garlic (Allium sativum) may be effective for attenuating endometrial pain. Suggested mechanisms for efficacy include modulation of inflammation and potent antioxidant effects. Aged-garlic-extract (AGE) is a centuries old process describing ethanolic extracts of garlic bulbs for 12-20 months. The AGE formulation realised contains a complex array of stabilised biologics with significant immunomodulatory effects relevant to inflammatory conditions. This perspective article puts forward a hypothesis that AGE should be considered as a prophylactic to manage endometrial pain.

Keywords: aged garlic extract; endometriosis; nutraceuticals; pain; prophylactic.